Materials Scientist

Compunnel Inc.

Ridgefield (CT)

On-site

USD 61,992 - 68,880

Full time

14 days+

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Job summary

A prominent biotechnology firm in Ridgefield is looking for a Scientist IV to apply solid-state NMR spectroscopy in pharmaceutical development. The ideal candidate should have a Master's in Organic Chemistry and experience with ssNMR methods. Tasks include characterizing materials and evaluating molecular structures. This contract position offers competitive hourly pay based on experience.

Qualifications

Experience with solid-state NMR sample preparation and data acquisition required.
Background in use of solution NMR for structure elucidation is highly desired.
Experience implementing and troubleshooting ssNMR experiments.

Responsibilities

Apply ssNMR for molecular structure elucidation.
Characterize pharmaceutical materials using ssNMR.
Ensure data backup and retrieval for all ssNMR data.

Skills

Solid-state NMR spectroscopy

Molecular modeling

Data interpretation

Excellent written communication

Education

Master's Degree in Organic Chemistry

Tools

Gaussian

Schrodinger

Materials Studio suite

Job description

This range is provided by Compunnel Inc.. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$45.00/hr - $50.00/hr

Direct message the job poster from Compunnel Inc.

Job Title: Scientist IV

Duration: 12+ Months

Job Summary:

The individual in this position will actively contribute to the discovery, development and delivery of our products to our patients and customers. global presence provides an opportunity to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance.

Duties & Responsibilities:

Apply skill in solid-state NMR (ssNMR) spectroscopy to acquire and interpret (1D and 2D 1H, 19F, 13C, 15N, etc.) data for molecular structure elucidation.

Apply ssNMR to characterize pharmaceutical materials such as particles, powders, and suspensions and to guide robust drug substance and drug product development.

Use NMR expertise to evaluate and characterize a broad range of materials, including crystalline and non-crystalline small molecule APIs, biologics, excipients, drug product intermediates, and drug products.

Apply quantitative ssNMR methods to measure components of APIs and drug products.

Use molecular modeling and predictive tools with technologies such as solution/solid state NMR and X-ray crystallography to enable 3D structural evaluation at the atomic and molecular level.

Ensure back-up and retrieval of all ssNMR data.

Plan and perform experiments with minimal supervision to provide investigative support of structural predictions.

Remain current with relevant scientific literature and apply knowledge to the design, modification and implementation of new experiments.

Write protocols, methods and technical reports; provide scientific interpretation of results with minimal guidance.

Present at internal scientific meetings.

Skills:

Requirements:

Background in use of solution NMR for structure elucidation is highly desired.

Experience with solid-state NMR sample preparation, data acquisition and interpretation of multinuclear NMR data is required.

Experience with implementing and trouble-shooting ssNMR experiments.

Experience changing Bruker ssNMR probes is required.

Basic understanding of molecular structure, inter-atomic distances, hydrogen bonding, torsion angle strain, hydrophobic and hydrophilic interactions.

Experience in the application and interpretation of ssNMR to study biological systems is a plus.

Understands the conceptual basis behind modern computational methods such as qm-DFT, Monte Carlo methods, etc.

Knowledgeable in the routine use of molecular modeling software (example: Gaussian, Schrodinger, Materials Studio suite, CCDC software )

Familiar with use of HPC clusters, Linux environment and associated job submission programs.

Experience collaborating with diverse teams and demonstrated ability to work independently and with minimal supervision.

Experience with preparing and analyzing membrane protein samples is a plus.

Excellent laboratory practices to ensure safety and sample integrity.

Excellent oral and written communication skills, highly organized and efficient record keeping.

Background in use of solution NMR for structure elucidation is desired.

Education:

Master's Degree in Organic Chemistry or equivalent with 1-3 yrs. experience in the application of ssNMR Spectroscopy to structurally characterize pharmaceutically relevant small molecules.

Seniority level