Material Science Senior Principal Scientist

Vertex France Distribution; Boston (MA); On-site; USD 162,000 - 244,000; Full time

Job summary

A leading biotechnology company seeks a Material Science Senior Principal Scientist in Boston, MA. This lab-based role involves leading experimental design for drug development, ensuring a deep understanding of materials properties. Candidates should have a relevant advanced degree with significant industry experience. The position also offers competitive pay, bonuses, and extensive benefits, supporting growth and work-life balance.

Benefits

Generous paid time off

Educational assistance programs

401(k) matching

Commuting subsidy

Annual bonus eligibility

Qualifications

• Deep understanding of solid form evaluation in drug development.
• Proficient in materials science and engineering principles.
• 6-8+ years of experience for PhD holders.

Responsibilities

• Design and implement experiments for solid form development.
• Provide technical recommendations and troubleshooting.
• Coordinate work for external publication.

Skills

Experimental design

Scientific creativity

Technical communication

Data reporting and analysis

Problem-solving

Project coordination

Education

PhD in Chemical or Materials engineering

Master's degree in relevant field

Bachelor's degree in relevant field

Tools

XRPD

ssNMR

TGA

DSC

DVS

IR

Raman

Job description

Material Science Senior Principal Scientist page is loaded

Material Science Senior Principal Scientist

Apply locations Boston, MA time type Full time posted on Posted 2 Days Ago job requisition id REQ-24459

Job Description

General Summary:

The Material Science Senior Principal Scientist is a self-reliant lab-based position with a proven record of accomplishments, that will support Vertex's drug development programs. They must possess a deep understanding of the relationship between materials properties, pharmaceutical processing conditions, and final product performance and quality attributes. A proven track record of applying in-depth conceptual knowledge of materials science and engineering principles to experimental design and execution is critical. Continuous improvement in materials and process understanding is expected, along with expertise in several relevant areas of materials science.

Key Duties and Responsibilities:

• Design and implement experiments to discover and characterize all potential solid form development options (polymorphism, salts, co-crystals, amorphous, etc) for drug substances and intermediates.
• Design, validate, and implement advanced characterization techniques and predictive models which connect material properties, pharmaceutical processing conditions, and final product performance in the interest of scaling down process development and streamlining formulation design.
• Represent form discovery group on cross functional teams to discuss solid form options for development and propose and agree a development path forward
• Design and implement tailored solid form evaluation packages to de-risk development of novel drug molecules
• Develops novel solutions to project obstacles and sets new experimental directions
• Makes substantive conceptual contributions to project activities and scientific strategies
• Provides authoritative technical recommendations and troubleshooting within own projects and assisting junior staff with their projects
• Coordinates generation of appropriate work for external publication
• Compiles intellectual property surrounding physical form discovery and understanding

Knowledge and Skills:

• Deep understanding of solid form evaluation and decision making within the drug development process.
• Exceptional experimental design, implementation, data reporting and analysis
• Demonstrates advanced judgment, balancing technical feasibility and scientific opportunity
• Demonstrates initiative and ability to capitalize on their own scientific creativity and assist that of team members
• Proven knowledge and experience in chemical/materials engineering and or materials/solids state science and principles
• Demonstrates advanced understanding of solid-state analytical techniques (XRPD, ssNMR, TGA, DSC, DVS, IR, Raman, etc.)
• Ability to function effectively within a dynamic environment
• Track record of successful implementations of innovative solutions
• Ability to plan and manage work performed at external CRO/CMOs
• A superior communicator, demonstrating the ability to write advanced technical documents and demonstrating confidence and versatility in presenting verbally to diverse audiences

Education and Experience:

• PhD in Chemical or Materials engineering or related Materials Science/Chemistry discipline with 6-8+ years of experience
• PhD in Chemical or Materials engineering or related Materials Science/Chemistry discipline with 6-8+ years of experience or the equivalent combination of education and experience with other degree levels
• Master's degree in Chemical or Materials engineering or related Materials Science/Chemistry discipline with 9+ years of experience
• Bachelor's degree in Chemical or Materials engineering or related Materials Science/Chemistry discipline with 11+ years of experience

Pay Range:

$162,500 - $243,800

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

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Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency .

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook , Twitter/X , LinkedIn , YouTube and Instagram .

The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.

Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.