Manager, Site Reliability Engineer New USA - South San Francisco, CA

Twist Bioscience Corporation; South San Francisco (CA); Hybrid; USD 210,000 - 243,000; Full time

Job summary

Twist Bioscience Corporation in South San Francisco is recruiting an experienced SRE Manager to lead Site Operations and ensure reliability of cloud infrastructure and critical applications.

You will drive automation, observability, and platform reliability across Kubernetes, DNS, CDN, and storage, partnering with software engineers to improve deployment and resilience. Strong leadership and security mindset are essential.

Qualifications

• 5–7+ years in Site Operations, SRE, or related roles.
• Experience leading engineering or operations teams.
• Hands-on cloud infrastructure experience (AWS/Azure/GCP).
• Production Kubernetes management experience.
• Strong networking knowledge including DNS, load balancing, and CDN tech.
• Observability/monitoring experience (Splunk).
• Scripting and automation with Python, Bash, Terraform.
• Experience building CI/CD pipelines and IaC practices.
• Excellent cross-functional collaboration.

Responsibilities

• Lead and manage the Site Operations / SRE function.
• Own cloud infrastructure architecture, operations, and optimization.
• Ensure high availability and reliability of production apps.
• Drive automation, monitoring, and incident management.
• Develop observability platforms with logging, metrics, alerts, and tracing.
• Manage Kubernetes-based infrastructure and container orchestration.
• Oversee DNS, CDN, storage across cloud environments.
• Collaborate with engineering to improve deployment and resilience.
• Establish CI/CD pipelines and IaC practices.
• Lead incident response and post-incident remediation.
• Mentor SRE engineers and foster reliability culture.
• Define security and compliance best practices.

Skills

Cloud platforms AWS/Azure/GCP

Kubernetes

Networking & CDN

Observability (Splunk)

Python scripting

Terraform (IaC)

CI/CD pipelines

Incident management

Leadership/mentoring

Security/compliance

Tools

Akamai CDN

Splunk

Job description

Manager, Site Reliability Engineer (Hybrid in South San Francisco)

About the Role

We are seeking an experienced and hands‑on Site Reliability Engineering (SRE) Manager to lead our Site Operations and infrastructure initiatives. This role is responsible for ensuring the reliability, scalability, security, and performance of our cloud infrastructure and critical applications.

The ideal candidate combines strong technical expertise with leadership experience and a passion for operational excellence. You will lead efforts across cloud infrastructure, observability, automation, networking, and platform reliability while partnering closely with engineering and product teams to support business-critical applications.

Responsibilities

• Lead and manage the Site Operations / SRE function
• Own cloud infrastructure architecture, operations, scalability, and optimization
• Ensure high availability and reliability of production applications and services
• Drive operational excellence through automation, monitoring, and incident management
• Develop and maintain observability platforms including logging, metrics, alerting, and tracing
• Manage Kubernetes-based infrastructure and container orchestration environments
• Oversee networking, DNS, CDN, and storage infrastructure across cloud environments
• Collaborate with software engineering teams to improve deployment processes, system resilience, and performance
• Establish and improve CI/CD pipelines and infrastructure-as-code practices
• Lead incident response, root cause analysis, and post-incident remediation efforts
• Manage vendor and platform relationships where applicable
• Mentor and develop SRE / Site Operations engineers and foster a culture of reliability and continuous improvement
• Define and implement infrastructure security and compliance best practices

Required Qualifications

• 5–7+ years of experience in Site Operations, Site Reliability Engineering, Infrastructure Engineering, or related operational roles
• Prior experience leading or mentoring engineering or operations teams
• Strong hands‑on experience with cloud infrastructure platforms (AWS, Azure, and/or GCP)
• Experience managing Kubernetes (K8s) environments in production
• Strong understanding of networking concepts including DNS, load balancing, firewalls, routing, and CDN technologies
• Experience with Akamai CDN administration and optimization
• Experience with observability and monitoring platforms, including Splunk
• Experience with storage infrastructure and cloud-native storage solutions
• Strong scripting and automation experience (Python, Bash, Terraform, or similar)
• Experience implementing and maintaining CI/CD pipelines
• Strong troubleshooting and incident management skills in complex distributed systems
• Excellent communication and cross‑functional collaboration skills

Preferred Qualifications

• Experience managing hybrid or multi‑cloud environments
• Experience with infrastructure-as-code and GitOps methodologies
• Familiarity with security best practices and compliance frameworks
• Experience supporting highly available enterprise or SaaS platforms
• Strong understanding of container security and cloud-native architectures

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

$210,383 - $243,210 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Twist Bioscience’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three‑year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.