Manager, Clinical Supply Chain

Rapport Therapeutics; Boston (MA); On-site; USD 125,000 - 145,000; Full time

Benefits offered by this job

Unlimited PTO

Lifestyle spending account

Commuting reimbursement

Competitive benefits

Job summary

Rapport Therapeutics in Boston is seeking a detail-oriented Manager, Clinical Supply Chain to support global supply chain operations for late-stage clinical development and commercialization readiness. You will work with CMC, Clinical Operations, Quality, and Regulatory teams to ensure continuous supply of investigational materials.

This hands-on role emphasizes day-to-day execution, demand forecasting, vendor coordination, and cross-functional alignment to enable Phase 3 programs and potential

Qualifications

• 3–5 years of progressive experience in global supply chain or clinical supply chain management within biopharmaceuticals.
• Bachelor's degree in Life Sciences, Engineering, Supply Chain, or related field.
• Experience supporting Phase 2/3 clinical trials.
• Experience supporting commercial supply chain activities is a plus.
• Understanding of GMP/GDP requirements and global regulatory expectations for small molecule therapeutics.
• Experience with external manufacturing, packaging, labeling, and logistics partners.
• Strong multitasking and cross-functional collaboration skills.
• ASCM/APICS CSCP/CPIM certification preferred.

Responsibilities

• Support global clinical supply planning and execution for Phase 3 trials, including demand forecasting and inventory tracking.
• Coordinate with CDMOs, packaging vendors, and logistics providers.
• Align supply plans with manufacturing campaigns, timelines, and regulatory milestones.
• Support readiness activities for pivotal trials and regulatory submissions.
• Provide end-to-end support of IRT/RTSM implementation and lifecycle management.

Skills

Global supply chain management

Cross-functional collaboration

Attention to detail

Communication skills

Education

Bachelor's degree in Life Sciences, Engineering, Supply Chain, or related field

Tools

ASCM/APICS CSCP/CPIM

Job description

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials in primary generalized tonic-clonic seizures (PGTCS) and bipolar disorder.

The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!

This role is located in Boston, MA with an onsite requirement of Monday-Wednesday every week.

Your Impact

Rapport Therapeutics is seeking a detail-oriented and execution-focused Manager, Clinical Supply Chain to support global supply chain operations for late-stage clinical development and commercialization readiness. As the company advances its lead programs through Phase 3 and prepares for potential regulatory submissions, this role will support the execution of reliable, compliant, and scalable supply across global clinical trials.

Reporting into Supply Chain leadership within CMC and Product Development, the Manager will support day-to-day global clinical supply planning and execution, vendor coordination, and cross-functional alignment to help ensure uninterrupted supply of investigational materials.

This role is ideal for a supply chain professional who enjoys hands-on execution and is comfortable managing detailed operational tasks while partnering closely with CMC, Clinical Operations, Quality, and Regulatory teams.

Your Day-to-day

Global & Clinical Supply Chain Execution

• Support global clinical supply planning and execution for Phase 3 trials, including demand forecasting, inventory tracking, production scheduling, and distribution coordination.
• Help ensure timely, compliant supply of drug substance, drug product, and clinical trial materials to global clinical sites on assigned programs.

CMC & Cross-Functional Integration

• Partner with CMC, Clinical Operations, Regulatory, Quality, and Program Management to align supply plans with manufacturing campaigns, clinical timelines, and regulatory milestones.
• Support supply chain readiness activities for pivotal trials.

Vendor & CDMO Management

• Support day-to-day relationships with CDMOs, packaging and labeling vendors, and logistics providers.
• Assist with contract execution, performance monitoring, issue resolution, and continuous improvement initiatives across external partners.

Supply Planning, Systems & Analytics

• Support clinical demand forecasting, inventory visibility, and supply reconciliation processes.
• Use supply chain systems, planning tools, and dashboards to support data-driven decision-making and scenario planning.
• Provide end-to-end support of IRT/RTSM implementation and lifecycle management, including URS development, system design and configuration, UAT, go-live readiness, drug supply and inventory transactions, and ongoing system changes, ensuring the IRT strategy supports clinical supply, study design, and operational requirements.

Operational Excellence & Risk Management

• Help identify supply chain risks related to capacity, lead times, regulatory requirements, or geopolitical factors, and support development of mitigation plans in partnership with leadership.
• Contribute to the development and refinement of SOPs, KPIs, and scalable processes to support company growth.
• Liaise with Clinical Operations teams for development of pharmacy manual, site trainings, etc. as it relates to drug supply handing and management at clinical sites.

Collaboration & Communication

• Collaborate effectively within supply chain initiatives and cross-functional project teams.
• Contribute to a culture of accountability, innovation, and continuous improvement aligned with company values and growth objectives.

Must-Haves

• 3–5 years of progressive experience in global supply chain or clinical supply chain management within the biopharmaceutical industry.
• Bachelor's degree in Life Sciences, Engineering, Supply Chain, or related field.
• Experience supporting Phase 2/3 clinical trials
• Experience supporting commercial supply chain activities is a plus.
• Understanding of clinical development processes, GMP/GDP requirements, and global regulatory expectations for small molecule therapeutics.
• Experience supporting external manufacturing, packaging, labeling, and logistics partners.
• Strong attention to detail and ability to manage multiple operational priorities simultaneously.
• Strong communication, problem-solving, and cross-functional collaboration skills.
• ASCM/APICS certification preferred (e.g. CSCP, CPIM)

What Makes Rapport Special

• Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas – we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
• Leadership that CARES – about you, your growth + development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.

Your Compensation

We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for the role to be $125,000 to $145,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

Hybrid Work Environment

We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office Monday-Wednesday to create more opportunities for innovation, collaboration, and connection.

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies

Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.