Manager, Biostatistics

Madrigal Pharmaceuticals; Conshohocken (Montgomery County); Vor Ort; USD 149.000 - 181.000; Vollzeit

Benefits dieser Stelle

Equity

Comprehensive benefits

Zusammenfassung

Madrigal Pharmaceuticals seeks an early-career Biostatistician to contribute to statistical activities across clinical development and post-marketing efforts. You will translate objectives into deliverables, support statistical strategies, and deliver high-quality analyses in collaboration with biostatisticians, programmers and cross-functional teams.

Reporting to the Senior Director of Biostatistics, you will work on trial design, real-world studies, and analysis of healthcare data, with

Qualifikationen

• Ph.D. in (Bio)statistics with 0-3 years, or a Master's degree with 5+ years in a Pharma/Biotech environment.
• Experience in design and analysis of clinical trials and healthcare datasets.
• Strong foundation in advanced statistical methods and computing (R, SAS).
• Excellent communication of complex statistical analyses to non-statisticians.
• Knowledge of regulatory guidelines in pharmaceutical development is a plus.
• Excellent organizational and communication skills.

Aufgaben

• Execute statistical modeling and analyses, coordinating with biostatisticians, programmers and cross-functional teams to meet R&D objectives.
• Perform and review complex statistical analyses, contribute to protocol development and prepare SAPs as needed.
• Contribute to the design of clinical and real-world studies and perform analyses to support evidence generation.
• Establish effective collaborations with cross-functional teams including clinical research and data management.
• Contribute to scientific excellence via statistical innovation and external conference participation.

Kenntnisse

R

SAS

Ausbildung

Ph.D. in (Bio)statistics

Master's in Biostatistics

Jobbeschreibung

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Manager, Biostatistics is an early-career individual contributor that will contribute to multiple biostatistical activities for Madrigal Pharmaceuticals, covering all phases of clinical development and post-marketing efforts. This role will support the translation of organizational objectives into statistical deliverables, contribute to the execution of statistical strategies, and deliver high-quality analytical outputs.

This role will collaborate with other biostatisticians, programmers and cross-functional team members either within the company or at a CRO partner to ensure that Madrigal's analytical objectives are met. This role provides hands‑on biostatistics experience in clinical development and post-marketing evidence generation, while building expertise under senior statistical guidance.

This position reports into the Senior Director of Biostatistics.

Responsibilities

• This role will execute statistical modeling and analyses, coordinating with other biostatisticians, programmers and cross-functional team members to meet R&D objectives.
• Perform and review complex statistical analyses, contribute to protocol development and prepare Statistical Analysis Plans as needed.
• Contribute to the design of clinical and real-world studies and perform analyses of clinical and real-world data to support evidence generation initiatives from randomized trials as well as observational studies.
• Establish effective collaborations with cross-functional team members, such as clinical research, medical affairs, clinical operations and data management.
• Contribute to scientific excellence via statistical innovation and participation in external conferences.

Qualifications

• Ph.D. in (Bio)statistics with 0-3 years, or a Master's degree with 5+ years of experience in a Pharma or Biotech environment.
• Experience in design and analysis of clinical trials and healthcare datasets.
• Solid foundation in advanced statistical methods and computing (R, SAS).
• Effectively communicates complex statistical analyses and concepts to non-statisticians.
• Knowledge of regulatory guidelines in pharmaceutical development is a plus.
• Excellent organizational and communication skills.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $148,760 - $181,276 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

• Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [e-mail].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.