Machine Learning Scientist, Biomolecular Structure Prediction

Profluent Bio; Emeryville (CA); Presencial; USD 212 000 - 339 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Competitive compensation with equity

401(k) with strong employer match

Comprehensive health/dental/vision

Generous PTO and work-life balance

Professional development opportunities

Resumo da oferta

Profluent Bio seeks an ML Scientist to drive biomolecular structure prediction research. You will build all-atom co-folding models focused on antibody–antigen interfaces and protein–nucleic acid assemblies, integrating with Profluent’s generative and experimental platforms.

The role requires a PhD or equivalent experience, hands-on model building, and publications or open-source contributions. Join an early ML team shaping AI-driven biology.

Qualificações

• PhD (or equivalent) in CS, computational biology, biophysics or related field.
• Hands-on experience building and training biomolecular structure-prediction models.
• Publications at ML venues or top journals, or open-source model usage.
• Experience with deep learning frameworks and multi-GPU training.

Responsabilidades

• Develop and train all-atom structure prediction models for antibody–antigen and protein–nucleic acid complexes.
• Diagnose failure modes and design architecture, training, and data interventions.
• Curate large-scale training data from structural databases and internal datasets.
• Integrate structure models with generative models for design and validation.
• Present results to colleagues in regular update meetings.

Conhecimentos

Biomolecular structure modeling

Deep learning (PyTorch/JAX)

Multi-GPU training

Formação académica

PhD in computer science / computational biology / biophysics

Ferramentas

PyTorch

JAX

Descrição da oferta de emprego

Profluent is the frontier AI lab for biology. Profluent builds powerful foundation models for all of life's molecules, unlocking solutions that transform medicine, agriculture, and beyond. Founded in 2022 and headquartered in Emeryville, CA, Profluent is backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures and has raised over $150M to date.

We're looking for a motivated and creative Machine Learning (ML) Scientist to drive research into biomolecular structure prediction. You will build and improve all-atom co-folding models, with a focus on the complexes that matter most to our programs: antibody–antigen interfaces and protein–nucleic acid assemblies. These remain among the hardest cases for current models, and closing that gap directly accelerates our antibody design and genome editing work.

The ideal candidate has trained structure prediction models at a leading academic or industry lab and knows where today's models break. You will be a self-directed researcher who moves quickly from hypothesis to trained model to rigorous evaluation. As an early member of the ML team, you will help shape how structure modeling fits alongside our generative models (ProGen3, E1) and experimental platforms.

Responsibilities

• Develop and train all-atom structure prediction models, improving accuracy on antibody–antigen and protein–nucleic acid complexes
• Diagnose failure modes of current models (e.g., CDR-H3 and epitope placement, interface geometry, nucleic acid conformations, confidence calibration) and design architecture, training, and data interventions to address them
• Curate large-scale training data from structural databases, distillation sets, and Profluent's own experimental binding and function data
• Integrate structure models with our generative models for design and filtering, and work with protein design teams on experimental validation
• Present results to colleagues in regular update meetings

Qualifications

• PhD (or equivalent industry experience) in computer science, computational biology, biophysics, or a related field
• Hands-on experience building and training biomolecular structure prediction models (e.g., AlphaFold- or Protenix-style co-folding models) at a leading academic or industry lab
• Publications at major ML conferences (NeurIPS, ICML, ICLR) or top science journals, or widely used open-source models
• Experience with deep learning frameworks such as PyTorch or JAX, including multi-GPU training

Preferences

• Experience modeling antibody structure and antibody–antigen docking, including CDR loop modeling and epitope prediction
• Experience modeling protein–DNA or protein–RNA complexes
• Deep familiarity with structural data pipelines: mmCIF processing, MSA and template search, structural clustering, and dataset splitting
• Experience with diffusion or flow-matching models for structure generation or structure-conditioned design
• Experience with large-scale distributed training and cloud compute
• Familiarity with experimental structural and binding data (cryo-EM, crystallography, display-based binding assays)

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

Hiring Salary Range $212,000 — $339,000 USD