Lead Purification Scientist, Downstream Process Development

Denali Therapeutics Inc.; South San Francisco (CA); Vor Ort; USD 159.000 - 207.000; Vollzeit

Benefits dieser Stelle

401k

Healthcare coverage

ESPP

Zusammenfassung

Denali Therapeutics Inc. seeks a Principal Scientist for Purification Process Development in South San Francisco. You will independently lead purification and downstream process characterization, support tech transfer, and oversee late‑stage data packages.

You will author protocols, coordinate studies, and guide internal and external teams to ensure high-quality data for regulatory submissions. The role requires a PhD with 10+ years in biology/biochemistry/chemical engineering, expertise in

Qualifikationen

• PhD in biology/biochemistry/chemical engineering with 10+ years of related experience.
• Experience with purification process characterization and validation is required.
• Experience coordinating with CMOs and batch record review is preferred.

Aufgaben

• Lead purification/downstream process development, characterization, tech transfer, and late-stage activities.
• Author protocols, coordinate studies, review results and IND/BLA sections.
• Coordinate teams to generate data packages for late-stage processes and PPQ campaigns.

Kenntnisse

Purification process characterization

Biochemical analysis

Cross-functional collaboration

Scientific problem-solving

Ausbildung

PhD in Biology/Biochemistry/Chemical Engineering

Tools

AKTA protein purification systems

Jobbeschreibung

Denali Therapeutics Inc. seeks a Principal Scientist for Purification Process Development in South San Francisco. You will independently lead purification and downstream process characterization, support tech transfer, and oversee late‑stage data packages.

You will author protocols, coordinate studies, and guide internal and external teams to ensure high-quality data for regulatory submissions. The role requires a PhD with 10+ years in biology/biochemistry/chemical engineering, expertise in