Lead Principal Scientist, Biologics Formulation

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 109,000 - 202,000; Full time

Benefits offered by this job

Health, life & disability benefits

401(k) with company match

Generous time off

Job summary

Novartis Institutes for BioMedical Research, Inc. is seeking a Principal Scientist to lead formulation development for complex biologics, including monoclonal antibodies and ADCs. The role involves guiding a team, shaping early development strategies, and partnering with CMC to advance clinical candidates.

The position offers exposure to diverse modalities and a focus on developing robust, scalable formulations with strong analytical oversight and cross-functional collaboration.

Qualifications

• PhD in biochemistry, biotechnology, chemistry, or related field with 2+ years of industry experience.
• Hands-on experience in protein formulations and biophysical property assessment.
• Experience leading scientific teams and managing development strategies.

Responsibilities

• Design and execute formulation screening strategies for large-molecule therapeutics.
• Lead studies to identify stable formulations and communicate results to cross-functional teams.
• Provide leadership and direction to team members as the functional manager.
• Partner with CMC teams to advance clinical candidates and drug product development.
• Develop stabilization strategies for liquid, frozen, and lyophilized formats.

Skills

Formulation development

Biologics

Monoclonal antibodies

Leadership

Team mentorship

Analytical methods

Preformulation

Communication

Cross-functional collaboration

Education

PhD in biochemistry/biotechnology/chemistry

Tools

DSC

DLS

SEC

HIC

UV-Vis

Turbidity

ELN

Automation

Job description

Novartis Institutes for BioMedical Research, Inc. is seeking a Principal Scientist to lead formulation development for complex biologics, including monoclonal antibodies and ADCs. The role involves guiding a team, shaping early development strategies, and partnering with CMC to advance clinical candidates.

The position offers exposure to diverse modalities and a focus on developing robust, scalable formulations with strong analytical oversight and cross-functional collaboration.