Lead, Preclinical Formulation Development

Socket.dev; Cambridge (MA); On-site; USD 122,000 - 174,000; Full time

Job summary

Relay Therapeutics is seeking a senior formulation scientist to lead early-stage formulation development for small molecules, focusing on oral dosage forms and enabling discovery programs. You will partner with biology, DMPK, and toxicology to advance candidates through DRF and GLP studies.

You will design preclinical and clinical formulations, perform stability testing, and guide CRO/CDMO activities while presenting data to management and collaborating across teams.

Qualifications

• Master’s or advanced degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry or related fields.
• Minimum of 6+ years of relevant experience in early-stage formulation development for small molecules with a focus on developing oral dosage forms.
• Hands-on experience with preclinical and clinical formulations using solutions, suspensions, emulsions, tablets and capsules.
• Experience with poorly soluble compounds using solid dispersions, nano-suspensions, lipid formulations and particle size reduction techniques.
• Thorough understanding of analytical techniques such as HPLC/UPLC, UV-Vis, IR, PXRD, DSC/TGA, DVS, GC, KF, particle size analysis, SEM.
• Strong pharma principles knowledge including PK and biopharmaceutics; PBPK modeling is a plus.
• Excellent written and verbal communication skills and ability to work with cross-functional teams.

Responsibilities

• Lead and manage formulation development activities to support pre-clinical research and early clinical programs.
• Design and develop discovery formulations to enable pharmacology and animal PK/tox studies.
• Plan pre-formulation and formulation development studies for initial clinical formulation and IND filing.
• Conduct stability studies to support advancement of discovery compounds.
• Coordinate with DMPK, toxicology, analytical teams to ensure timely manufacture and supply of formulations to CROs/CDMOs.
• Collaborate with discovery groups to develop formulation protocols for DRF and GLP studies.
• Develop plans for manufacturing, testing, and analysis of pre-clinical and early-stage formulations at CROs/CDMOs.
• Present data in technical meetings and provide guidance on formulation challenges.
• Design polymorph screening studies and recommend suitable forms for development.
• Perform developability risk assessments for investigational compounds.

Skills

Pharmaceutics

Formulation development

Preclinical studies

Analytical techniques

Team collaboration

Problem solving

Education

Master’s or advanced degree in Pharmaceutics or Pharmaceutical Sciences

Tools

HPLC/UPLC

UV-Vis

IR

PXRD

DSC/TGA

Particle size analysis

Job description

Relay Therapeutics is seeking a senior formulation scientist to lead early-stage formulation development for small molecules, focusing on oral dosage forms and enabling discovery programs. You will partner with biology, DMPK, and toxicology to advance candidates through DRF and GLP studies.

You will design preclinical and clinical formulations, perform stability testing, and guide CRO/CDMO activities while presenting data to management and collaborating across teams.