Lead Optical Architect for DNA Sequencing Systems

BioTalent; San Diego (CA); On-site; USD 175,000 - 210,000; Full time

Job summary

BioTalent is seeking a Principal Optical Engineer in San Diego, CA to own the optical architecture of a next-generation DNA sequencing platform from concept to commercialization.

You will drive design, simulation, tolerancing, and characterization of a high-sensitivity detection system, collaborating with cross-functional and CRO/CDMO teams to bring a manufacturable product to market.

Qualifications

• MS or PhD in Optical Engineering or related field.
• 5–10+ years of optical engineering experience with multiple products commercialized.
• Expert-level Zemax OpticStudio knowledge.
• Hands-on bench alignment, testing and characterization.
• Experience with CRO/CDMOs and contract manufacturers on design transfer.
• Strong knowledge of aberrations, diffraction, radiometry, polarization and detectors.
• Experience in ultra-high-sensitivity detection and life science instruments (preferred).

Responsibilities

• Define optical architecture and strategy for high-throughput DNA sequencing platforms.
• Lead end-to-end design, modeling, and optimization of illumination, imaging, and detection paths.
• Perform optical design, ray tracing, tolerance analysis, and stray-light analysis in Zemax OpticStudio.
• Build, align, test, and characterize optical prototypes and subsystems on the bench.
• Define specs for custom optical components, coatings, and sources; own supplier drawings and acceptance criteria.
• Partner with manufacturing contractors to transfer designs from prototype to volume production.
• Lead the optical system through feasibility, design verification, design transfer, and commercial launch.
• Collaborate with mechanical, electrical, software, and assay teams for full instrument integration.

Skills

Optical design

Zemax OpticStudio

Bench testing

Tolerance analysis

Design transfer

Education

MS/PhD in Optical Engineering or related field

Tools

Zemax OpticStudio

Job description

BioTalent is seeking a Principal Optical Engineer in San Diego, CA to own the optical architecture of a next-generation DNA sequencing platform from concept to commercialization.

You will drive design, simulation, tolerancing, and characterization of a high-sensitivity detection system, collaborating with cross-functional and CRO/CDMO teams to bring a manufacturable product to market.