Lead Multi-Omic Bioinformatician (Research Scientist)

CU Denver; Aurora (CO); Hybrid; USD 90,000 - 105,000; Full time

Benefits offered by this job

Health insurance

Dental options

Retirement plan

Paid time off

Job summary

University of Colorado Anschutz Medical Campus in Aurora, CO, invites applications for a Lead Bioinformatician/Research Scientist to drive multi-omics analysis within Ophthalmology. The role focuses on developing reproducible analytical workflows for a translational biorepository, integrating immunologic, proteomic, genomic and clinical data, and guiding long-term data strategy.

The position emphasizes collaboration with clinicians and scientists, providing technical leadership, code review, and

Qualifications

• Master's degree in bioinformatics, computational biology, biostatistics, or data science.
• Four years of professional or research bioinformatic analyses, with substantial independent responsibility.
• Experience with complex analyses involving multiple biological data modalities.
• Proficiency in R and Python.
• Experience developing reproducible bioinformatic workflows and using version control.
• Experience performing quality control, statistical analysis, visualization, and biological interpretation of high-dimensional biomedical data.
• Experience collaborating with both computational and non-computational investigators.
• Experience independently organizing work, managing timelines, and contributing to multiple concurrent research projects.

Responsibilities

• Lead analysis and integration of PhIP-Seq, CYTOF, affinity-based and mass-spectrometry proteomics, clinical data, and externally analyzed WGS results.
• Develop analysis plans addressing biomarkers of disease subtype, prognosis, and treatment response.
• Apply and evaluate multi-omic methods including CCA, MOFA and related latent-factor models, WGCNA, pseudobulk analysis, cell-state and cell-cell communication analysis, and predictive modeling.
• Lead secondary projects involving single-cell RNA sequencing and spatial transcriptomics.
• Perform raw-data processing, quality assessment, normalization, statistical analysis, biological interpretation, and visualization.
• Prepare publication-quality figures and contribute to manuscripts, abstracts, presentations, and grant applications.
• Serve as a coauthor on collaborative work, with opportunities to lead analytically focused manuscripts.

Job description

University of Colorado Anschutz Medical Campus in Aurora, CO, invites applications for a Lead Bioinformatician/Research Scientist to drive multi-omics analysis within Ophthalmology. The role focuses on developing reproducible analytical workflows for a translational biorepository, integrating immunologic, proteomic, genomic and clinical data, and guiding long-term data strategy.

The position emphasizes collaboration with clinicians and scientists, providing technical leadership, code review, and