Lead Bioinformatician, Multi-Omic Translational Research

University of Colorado Anschutz; Aurora (CO); Hybrid; USD 90,000 - 105,000; Full time

Benefits offered by this job

Medical options

Dental options

Disability insurance

Life insurance

Vision insurance

Retirement 401(a) Plan

Paid Time Off

Vacation days

Sick days

Holiday days

Tuition benefit

ECO Pass

Job summary

University of Colorado Anschutz in Aurora, CO seeks a Lead Bioinformatician to provide scientific and technical analysis for a translational biorepository. You will develop reproducible workflows, integrate multi-omic data, and collaborate with clinicians and scientists to shape research questions and data strategy.

The role includes mentoring one to three analysts, leading analytical projects, and delivering publication-quality figures and manuscripts.

Qualifications

• Masters degree in bioinformatics, computational biology, biostatistics, or data science.
• Four years of professional or research experience conducting bioinformatic or computational analyses.
• Experience with three or more omics or high-dimensional data types.
• Proficiency in R and Python.
• Experience developing reproducible bioinformatic workflows and using version control.
• Experience training or mentoring analysts, students, or research staff.

Responsibilities

• Lead analysis and integration of PhIP-Seq, CYTOF, affinity-based and mass-spectrometry proteomics, clinical data, and externally analyzed WGS results.
• Develop analysis plans addressing biomarkers of disease subtype, prognosis, and treatment response.
• Apply multi-omic methods including CCA, MOFA and related latent-factor models, WGCNA, pseudobulk analysis, cell-state and cell-cell communication analysis, and predictive modeling.
• Lead secondary projects involving single-cell RNA sequencing and spatial transcriptomics.
• Perform raw-data processing, quality assessment, normalization, statistical analysis, biological interpretation, and visualization.
• Prepare publication-quality figures and contribute to manuscripts, abstracts, presentations, and grant applications.
• Mentor one to three junior analysts or research staff.
• Help prioritize analytical requests and support management of multiple projects.

Skills

R

Python

Data visualization

Reproducible research

Mentoring

Project management

Education

Masters degree in bioinformatics, computational biology, biostatistics, or data science

Four years of professional or research experience in bioinformatics

Tools

Nextflow

Snakemake

Docker

HPC / cloud computing

Job description

University of Colorado Anschutz in Aurora, CO seeks a Lead Bioinformatician to provide scientific and technical analysis for a translational biorepository. You will develop reproducible workflows, integrate multi-omic data, and collaborate with clinicians and scientists to shape research questions and data strategy.

The role includes mentoring one to three analysts, leading analytical projects, and delivering publication-quality figures and manuscripts.