Lead Metabolic Strain Engineer — Strategy & Scale-Up

BioPhase Inc.; San Diego (CA); Sur place; USD 140 000 - 190 000; Plein temps

Résumé du poste

BioPhase Inc. in San Diego, CA seeks a strain engineer to lead an end-to-end metabolic engineering program. You will set strategy, build production strains, and use fermentation data to steer successive engineering rounds toward scalable outcomes.

You will mentor associates, maintain rigorous documentation, and collaborate with fermentation and analytics teams to ensure process-relevant performance.

Qualifications

• PhD or BS/MS with relevant years of industry experience as specified.
• Demonstrated genetic/metabolic engineering in microbes, including non-conventional yeasts.
• Experience with plasmid-based and genomically integrated expression constructs.
• Experience across plate, shake-flask, and bioreactor formats.
• Bioinformatics experience incl. genomics and transcriptomics.
• Hands-on DNA design, assembly, and sequencing.
• CRISPR genome editing experience.
• Strong documentation and cross-functional collaboration.

Responsabilités

• Lead strain and metabolic engineering to overproduce target molecules in microbial hosts.
• Design metabolic engineering strategies including pathway selection, flux and redox balancing.
• Design and build genetic constructs end to end (DNA design, assembly, verification).
• Optimize plasmid-based and genomically integrated expression constructs (promoters, loci, codon optimization).
• Develop genetic toolbox for non-conventional hosts and screening methods.
• Run screening pipelines across plate, shake-flask, and bioreactor formats.
• Analyze pathways and fermentation data to identify bottlenecks and guide iterations.
• Collaborate with fermentation, downstream processing, and analytics teams for scale-up.
• Maintain SOPs, strain records, and transfer packages.
• Mentor scientists and uphold rigorous experimental practices.
• Model biosafety and chemical hygiene standards.

Connaissances

Metabolic engineering

Synthetic biology

Microbiology

Fermentation data analysis

Problem solving

Documentation

Mentoring

Biosafety

Formation

PhD in Metabolic Engineering or related field

BS/MS +5 years industrial strain engineering experience

Outils

CRISPR genome editing

DNA design & assembly

DNA sequencing

Genomics data analysis

Description du poste

BioPhase Inc. in San Diego, CA seeks a strain engineer to lead an end-to-end metabolic engineering program. You will set strategy, build production strains, and use fermentation data to steer successive engineering rounds toward scalable outcomes.

You will mentor associates, maintain rigorous documentation, and collaborate with fermentation and analytics teams to ensure process-relevant performance.