Lead Medicinal Chemist, Small Molecule Discovery

Elanco US; Indianapolis (IN); Hybrid; USD 180,000 - 240,000; Full time

Benefits offered by this job

Hybrid work environment

Comprehensive benefits package

Job summary

Elanco is seeking a Principal Research Scientist in Medicinal Chemistry to guide the design and synthesis of novel small molecules across multiple therapeutic programs. You will partner with Biology, Pharmacology, and DMPK to advance discovery with cutting-edge technologies like DNA-Encoded Libraries and AI-driven design.

The role emphasizes leadership, collaboration, and delivering innovative medicines for animal health, with a hybrid work setup in Indianapolis.

Qualifications

• PhD in Medicinal Chemistry or related field.
• 8–10 years in medicinal chemistry in pharma/biotech animal health.
• Strong SAR, ADME/PK, pharmacology knowledge; lead cross-functional initiatives.

Responsibilities

• Drive design/optimization of novel small molecules using SAR and data integration.
• Lead medicinal chemistry initiatives with Biology, Pharmacology, DMPK, Toxicology, etc.
• Collaborate with CROs and internal partners to meet project goals/timelines.
• Navigate external collaborations with CROs and internal teams.
• Utilize DEL, computational chemistry, and AI/ML tools to speed hit-to-lead.
• Contribute to IP strategy with the IP team.
• Mentor junior scientists and foster innovation.

Skills

Modern medicinal chemistry

SAR expertise

Cross-functional collaboration

CRO management

Education

PhD in Medicinal Chemistry

Tools

DNA-Encoded Libraries (DEL)

Computational chemistry

AI/ML in design

Job description

Elanco is seeking a Principal Research Scientist in Medicinal Chemistry to guide the design and synthesis of novel small molecules across multiple therapeutic programs. You will partner with Biology, Pharmacology, and DMPK to advance discovery with cutting-edge technologies like DNA-Encoded Libraries and AI-driven design.

The role emphasizes leadership, collaboration, and delivering innovative medicines for animal health, with a hybrid work setup in Indianapolis.