Lead HR Business Partner- US BioPharmaceuticals

AstraZeneca plc; Wilmington (DE); Hybrid; USD 140,000 - 200,000; Full time

Job summary

AstraZeneca plc in Wilmington, DE is seeking a Lead HR Business Partner to shape and deliver the people strategy for US BioPharmaceuticals. The role offers a hybrid schedule with an average of three days in the office and requires a trusted advisor to senior leaders on talent, culture, and workforce plans.

As part of the US BBU HR Leadership Team, you will partner with Centers of Excellence, lead talent reviews, and drive change initiatives.

Qualifications

• Bachelor’s degree in Human Resources, Business, Psychology, or a related field.
• 7+ years HR experience in a large, matrixed/global organization, preferably HR client-facing.
• Digitally savvy with experience driving innovative HR solutions and continuous improvement.
• Proven track record of developing and executing HR/people strategies with measurable results.
• Trusted advisor and coach to business leaders.
• Excellent written and verbal communication; ability to influence senior leaders.
• Experience using HR analytics and organizational data for decision making.

Responsibilities

• Contribute to the Commercial workforce plan and participate on the US BBU HR Leadership Team.
• Develop and execute an integrated people strategy aligned with business priorities.
• Provide strategic counsel, challenge, and executive coaching to senior leaders.
• Partner with HR Centers of Excellence to deliver talent management, rewards, performance, and leadership development solutions.
• Lead talent reviews, succession planning, and leadership development for future needs.
• Identify capability gaps and design organizational, talent and culture interventions.
• Shape organizational design and operating models to support transformation and growth.
• Lead large-scale change initiatives with stakeholder engagement and adoption.
• Use people analytics and external trends to inform decisions and measure impact.
• Apply financial acumen including budgeting and FTE management to support the people agenda.
• Drive innovation with digital technologies, AI, automation to improve processes and experiences.

Job description

Human Resources

Hybrid Work- on average 3 days a week from office The Lead HR Business Partner (HRBP) is a critical member of the US BioPharmaceuticals (US BBU) HR Leadership Team, accountable for shaping and delivering the people strategy that enables the Commercial business to achieve its ambitions. This role serves as a trusted advisor to senior leaders, translating business priorities into talent, organization, culture, and workforce strategies that drive sustainable performance.

Wilmington, DE Human Resources The Lead HR Business Partner (HRBP) is a critical member of the US BioPharmaceuticals (US BBU) HR Leadership Team, accountable for shaping and delivering the people strategy that enables the Commercial business to achieve its ambitions. This role serves as a trusted advisor to senior leaders, translating business priorities into talent, organization, culture, and workforce strategies that drive sustainable performance. The Lead HRBP has accountability for designing and implementing an integrated people strategy across an assigned client group, partnering closely with HR Centers of Excellence and HR colleagues to deliver exceptional employee and leadership experiences. The role combines strategic leadership, organizational effectiveness, talent development, workforce planning, change leadership, and coaching to ensure the business is equipped with the capabilities, leadership, and culture needed for future success. This role reports to the Vice President of HR, USBBU.

What You'll Do

• Contribute to the Commercial strategic workforce plan and the enterprise people and talent agenda through active participation on the US BBU HR Leadership Team.
• Develop and execute an integrated people strategy aligned with the organization's vision, business priorities, and long-term objectives.
• Serve as a trusted advisor to senior leaders, providing strategic counsel, challenge, and executive coaching to enhance leadership effectiveness and team performance.
• Partner with HR Centers of Excellence to deliver effective and efficient solutions across talent management, rewards, performance, leadership development, employee experience, workforce planning, and recruitment.
• Lead strategic talent reviews, succession planning, and leadership development efforts to build a strong and diverse pipeline of talent for current and future business needs.
• Identify organizational capability gaps and design actionable organization, talent, and culture interventions that drive business performance.
• Partner with leadership teams to shape organizational design, team effectiveness, and operating model decisions that support business transformation and growth.
• Lead and support large-scale business change initiatives, ensuring thoughtful change management, stakeholder engagement, and adoption.
• Use people analytics, workforce insights, and external trends to inform decision-making, identify opportunities, and measure the impact of HR strategies and interventions.
• Apply foundational financial acumen including budgeting, FTE management, and facilitating demand planning activities to support the people agenda
• Drive innovation and continuous improvement by leveraging digital technologies, AI, automation, and data-driven solutions to simplify processes, enhance the employee experience, improve decision‑making, and create more efficient ways of working across the organization.

Essential For The Role

• Bachelor’sDegree inin Human Resources, Business, Psychology, or a related field
• 7+ years of HR experience within a large, sophisticated, and matrixed/globalorganization– preferably in HR client-facing role.
• Digitally‑savvy, with evidence of driving innovative solutions and a continuous improvement approach to HR implementation.
• Demonstrabletrack recordof leading the development and execution of HR and people strategies with measurable results.
• Solid experience as a trusted advisor and coach to business leaders.
• Excellent written and verbal communication skills, with the ability to influence, challenge, and negotiate at senior levels in an international environment.
• Demonstrated use of HR analytics andorganizationaldata to inform decision‑making, develop interventions, and evaluate impact.

Desirable for the role

• Master's degree
• Project and change management experience
• Leadership of teams and team effectiveness skills
• Understanding ofUS employment law, policy, and risk management.

Office Working Requirements

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Date Posted

21-Oct-2026

Closing Date

30-Oct-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.