Lead High-Throughput Molecular Production Supervisor

Twist Bioscience Corporation; South San Francisco (CA); On-site; USD 62,000 - 69,000; Full time

Job summary

Twist Bioscience Corporation seeks a Manufacturing Supervisor for NGS TE Production in South San Francisco, CA. You will train and lead staff in high‑throughput molecular workflows, ensure SOP adherence, and drive continuous process improvement in a LEAN, GMP/ISO‑aligned setting.

You will oversee batch records, calibrate equipment, and coordinate shift activities while maintaining 5S and safety standards. Strong molecular biology skills and leadership are essential.

Qualifications

• Minimum 5 years of lab experience in a manufacturing environment.
• A.S. or B.S. in Biology, Chemistry, or Biochemistry.
• Experience operating liquid handlers such as Hamilton and Tecan.
• Experience with instrumentation for PCR, cell-based cloning, miniprep extraction, and purification is a huge plus.
• Experience with sample tracking software and with interfaces between robotic instrumentation and LIMS/MES systems.
• Experience working in ISO, GMP, and LEAN manufacturing environments and applying lean manufacturing concepts.
• Excellent scientific computation and data analysis skills.
• Experience leading small teams in a laboratory environment.

Responsibilities

• Manufacture high-quality gene products in a high-throughput lab according to SOPs.
• Document thoroughly in batch records and databases, including problems and deviations.
• Operate semi-automated and automated lab equipment for molecular workflows.
• Track product quality using physical and functional tests.
• Troubleshoot test results and apply scientific problem-solving.
• Lead shift pass-downs and prioritize workflows.

Skills

Lab leadership

Lean manufacturing

GMP/ISO knowledge

PCR & cloning

LIMS/MES interfaces

Data analysis

Education

Biology/Chemistry/Biochemistry degree

Tools

Hamilton

Tecan

Job description

Twist Bioscience Corporation seeks a Manufacturing Supervisor for NGS TE Production in South San Francisco, CA. You will train and lead staff in high‑throughput molecular workflows, ensure SOP adherence, and drive continuous process improvement in a LEAN, GMP/ISO‑aligned setting.

You will oversee batch records, calibrate equipment, and coordinate shift activities while maintaining 5S and safety standards. Strong molecular biology skills and leadership are essential.