Lead Computational Protein Engineer for Antibody Design

MESO SCALE DIAGNOSTICS, LLC.; Rockville (MD); On-site; USD 117,000 - 178,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

401(k) with company matching

Paid vacation and sick leave

Job summary

MSD is seeking a science-driven leader to plan and develop an in-silico platform for antibody and protein engineering in collaboration with cross-functional teams. You will design workflows for de novo antibody and protein design, integrating data from multiple sources to optimize interactions.

The role requires PhD-level expertise, strong publication history, and leadership abilities to manage interdisciplinary teams and drive strategic initiatives within the department.

Qualifications

• PhD in structural bioinformatics, molecular biology, bioengineering, biophysics, computational biology, or related field with 2 years of relevant experience.
• Expertise with protein and antibody modeling, including antigen-antibody interactions.
• Publications in high-profile papers/patents within protein prediction or de novo protein design, including antibody or enzyme engineering.
• Experience with artificial intelligence and/or machine learning methods is desirable.

Responsibilities

• Independently designs and develops an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company.
• Develops computational pipelines for protein structure determination using structural and/or sequence-based methods and/or AI methods (e.g. Rosetta, AlphaFold).
• Develops computational pipelines for protein docking and antibody epitope mapping.
• Leads a technical team to implement computational pipelines in protein design, engineering, or prediction.
• Presents findings/analyses and any associated issues/solutions to peer groups and managers; make recommendations for project advancement.
• Leads cross-functional initiatives with other business units on projects/products or associated deliverables.

Skills

Leadership

Communication

Analytical thinking

Independent work

Education

PhD in structural bioinformatics or related field

Tools

Rosetta

AlphaFold

Microsoft Office

Job description

MSD is seeking a science-driven leader to plan and develop an in-silico platform for antibody and protein engineering in collaboration with cross-functional teams. You will design workflows for de novo antibody and protein design, integrating data from multiple sources to optimize interactions.

The role requires PhD-level expertise, strong publication history, and leadership abilities to manage interdisciplinary teams and drive strategic initiatives within the department.