Lead Bioinformatics Scientist (Oncology)

Bazeta; United States; Remote; USD 131,000 - 164,000; Full time

Benefits offered by this job

Competitive benefits

Remote USA

Job summary

Natera is seeking a Lead Bioinformatics Scientist to join the Oncology Bioinformatics team, focusing on the development, validation, and clinical application of NGS-based assays. You will shape analytical validation strategies, drive real-world evidence studies, and build pipelines integrating data across products.

The role requires strong NGS expertise, wet-lab collaboration, and the ability to translate complex data into actionable clinical insights within a fast-paced environment.

Qualifications

• Master’s degree in bioinformatics or related field with substantial post-grad experience.
• PhD with 5+ years post-grad experience preferred.
• Strong background in data analysis for wet lab support and NGS data.

Responsibilities

• Lead analytical validation strategy for an NGS-based assay with bench scientists and biostatisticians.
• Drive real-world evidence studies showing clinical utility for therapy selection and patient management.
• Build rapid prototypes and pipelines for multi-source data integration from different Natera products.
• Develop algorithms and tools to support new products in the production bioinformatics pipeline.
• Act as an internal technical consultant on bioinformatics methods.

Skills

NGS data analysis

Python

R

Shell

Data visualization

Cross-functional collaboration

Problem solving

Education

Master’s degree in bioinformatics

PhD (preferred)

Tools

Python

R

Shell

Job description

# Lead Bioinformatics Scientist (Oncology)United States2 hours agoID 4699116Price on request## DetailsEmployment type: Full-timeRemote: YesCompany: NateraLevel: Senior## DescriptionNatera is seeking a Lead Bioinformatics Scientist to join our Oncology Bioinformatics team and support the development, validation, and clinical application of our NGS-based assays. The ideal candidate has a strong background in data analysis for wet lab support and extensive experience with NGS data, with a focus on building solutions for oncology applications. In this role, you will shape the analytical validation strategy for an NGS assay, design and analyze feasibility and performance evaluation studies, and generate real-world evidence demonstrating its clinical utility. You will work with interdisciplinary teams to turn complex, multi-source data into actionable recommendations, supporting research, product development, validation, regulatory submissions, clinical studies, and scientific publications. PRIMARY RESPONSIBILITIES: • Lead the analytical validation strategy for an NGS-based assay, including designing, analyzing, and troubleshooting feasibility and performance evaluation studies (e.g., PPA and LoD) with bench scientists and biostatisticians. • Drive real-world evidence (RWE) studies that demonstrate the clinical utility of for therapy selection and patient management, from cohort selection through analysis of plasma mutation calls. • Build rapid prototypes and pipelines for custom analyses that integrate data from multiple Natera products. • Develop algorithms and tools to support new products, including contributions to the production bioinformatics pipeline. • Act as an internal technical consultant on bioinformatics methodology for other functional groups. • Work closely with assay development, engineering, biostatistics, clinical, commercial, regulatory, and lab operations teams. • Contribute to regulatory submissions, clinical study reports, and scientific publications. QUALIFICATIONS • Master’s degree in bioinformatics (or a related field) with 10 years of post-graduate experience, or PhD with 5 years of post-graduate experience (preferred). KNOWLEDGE, SKILLS, AND ABILITIES: • Expert knowledge of bioinformatics tools for NGS, including sequencing QC and secondary analysis such as variant calling. • Experience with WES/WGS/targeted sequencing of tissue and cfDNA, and with somatic variant calling (SNVs, indels, CNVs, fusions) on these data. • Working knowledge of statistical methods for assay performance evaluation, and ability to collaborate with biostatisticians on study design. • Strong programming and scripting skills in Python, R, and shell. • Fluency in exploratory data analysis and visualization of complex datasets, with the ability to distill observations into actionable recommendations. • Deep understanding of NGS workflows from sample extraction to sequencing, and the ability to link bioinformatic findings to wet lab root causes. • Ability to communicate effectively with wet lab groups and cross-functional partners, and to explain technical concepts clearly. • Ability to work independently while managing multiple objectives and timelines. • Comfort adapting quickly when experimental results change the plan, and a desire to work in a fast-paced environment with high impact in a small team. PREFERRED: • Experience supporting regulated or clinical-grade assay development (e.g., CLIA/CAP, FDA submissions), including analytical validation studies. • Familiarity with clinical genomics, including oncogenic drivers, actionable biomarkers, targeted therapies, and variant interpretation in oncology. • Experience with translational or real-world data analysis, including integrating clinical and genomic data. The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $130,900—$163,600 USD OUR OPPORTUNITY NateraTM is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! For more information, visit www.natera.com . Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.... Source: Jobicy (https://jobicy.com/jobs/158496-lead-bioinformatics-scientist-oncology)This listing comes from a partner feed. Apply on the source website.