LC-MS Chemist - Metabolism

Labcorp; Madison (WI); On-site; USD 85,000 - 115,000; Full time

Benefits offered by this job

Medical

Dental

Vision

Life

401(k)

PTO/FTO

Tuition Reimbursement

Employee Stock Purchase Plan

Job summary

Labcorp in Madison, WI is seeking an LC-MS Chemist - Metabolism to perform method validation, LC-MS/MS bioanalysis and data interpretation in a GLP/GCP-regulated environment.

The role includes collaborating with cross-functional teams, mentoring staff, and contributing to process improvements while delivering high-quality bioanalytical data.

Qualifications

• Bachelor's degree in Life Sciences or related field.
• 1.5+ years of hands-on LC-MS/MS bioanalysis experience.
• Experience with ADME/PK assays is a plus.
• Experience operating triple quadrupole mass spectrometers.

Responsibilities

• Perform routine to moderate-level method validation in GLP/GCP environment.
• Execute advanced method validation tasks with guidance from Lead Scientist.
• Interpret data and resolve issues with instrumentation.
• Review reports, SOPs and maintain audit-ready documentation.
• Communicate deviations and corrective actions promptly.
• Manage project work and deliver data to internal clients on schedule.
• Collaborate with Bioanalytical team and external clients.

Skills

LC-MS/MS bioanalysis

Method validation

Regulatory compliance

Data interpretation

Team mentoring

Project coordination

Cross-functional collaboration

Communication skills

Education

Bachelor's degree in Life Sciences/related

Master's degree in Life Sciences/related

Tools

MassLynx

MassHunter

Analyst

Orbitrap systems

Job description

Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improve outcomes. Through our unparalleled science, data, technology and laboratory network, we advance diagnostics, accelerate innovation and help address some of the world’s most important health challenges. As we shape the future of healthcare, we are leveraging advanced technologies, intelligent digital solutions and data-driven innovation across our operations to enhance how work gets done and deliver greater value to customers and patients. With our global scale and deep expertise, you’ll have the opportunity to do meaningful work, grow your career and make a real impact on people’s health around the world. Together, we’re improving health and improving lives.

Labcorp is seeking an LC-MS Chemist - Metabolism to join our team in Madison, WI.

Work Schedule: Monday - Friday 8:00 am - 5:00 pm

Job Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
• Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
• Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
• Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
• Collaborate effectively with colleagues across the Bioanalytical site and support cross-functional communications with external clients.
• Train and mentor less experienced laboratory staff.
• Contribute to process improvement initiatives and participate in department-wide quality initiatives.
• Maintain a clean, safe, and organized laboratory environment.

Minimum Qualifications

• Bachelor’s degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1.5 or more years of hands-on experience with LC-MS/MS bioanalysis, including MRM-based quantitation and method execution.
• 1.5 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK-MDR1), and PK sample processing (plasma, tissue lysates).
• 1.5 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

Preferred Qualifications

• Master’s degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1 or more years of exposure to CYP inhibition or Time-Dependent Inhibition (TDI) assays and drug-drug interaction (DDI) studies.
• 1 or more years of experience assisting in the development or optimization of new bioanalytical methods.

Additional Job Standards

• Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
• Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
• Strong attention to detail with demonstrated ability to generate reproducible, high-quality bioanalytical data.
• Familiarity with Orbitrap platforms or other high-resolution mass spectrometry systems.
• Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
• Experience working in a GLP/GCP-regulated environment (CRO or pharmaceutical/biotech industry).
• Excellent written and verbal communication skills.
• Proven ability to prioritize workloads and manage time effectively in a fast-paced laboratory environment.

Benefits:

Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including:

• Medical
• Dental
• Vision
• Life
• STD/LTD
• 401(k)
• Paid Time Off (PTO) or Flexible Time Off (FTO)
• Tuition Reimbursement
• Employee Stock Purchase Plan.

Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan.

For more detailed information, please.

Labcorp is proud to be an Equal Opportunity Employer:

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

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