LC-MS Chemist - Metabolism

Labcorp; Madison (WI); On-site; USD 70,000 - 90,000; Full time

Job summary

Labcorp in Madison, WI seeks an LC-MS Chemist – Metabolism to join our team. Work schedule is Mon-Fri 8:00 am - 5:00 pm, performing method validation and analytical support in a GLP/GCP-regulated environment.

The role requires 1.5+ years in LC-MS/MS bioanalysis, ADME/PK assays, and operating triple quadrupole platforms. Preferred are a Master’s degree and experience with regulatory guidelines; strong data integrity and cross-functional collaboration are essential.

Qualifications

• 1.5+ years hands-on LC-MS/MS bioanalysis, including MRM-based quantitation.
• 1.5+ years ADME/PK assays such as liver microsomal stability and permeability assays.
• 1.5+ years operating triple quadrupole mass spectrometers.

Responsibilities

• Organize and independently perform routine to moderate-level method validation per SOPs and GLP/GCP.
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply data interpretation and analytical instrumentation skills to resolve problems.
• Maintain audit-ready study documentation and review reports/methods/SOPs.

Skills

LC-MS/MS

ADME/PK

Triple quadrupole MS

MRM quantitation

Education

Bachelor's degree in Life Sciences/C Chemistry/ Biotechnology

Master's degree in Life Sciences/Chemistry/Biotechnology

Tools

MassLab software (MassLynx)

MassHunter

Analyst

Orbitrap familiarity

Job description

Labcorp is a global leader in laboratory services, providing the insights and answers that help healthcare providers, patients, researchers, pharmaceutical companies and health systems make confident decisions and improve outcomes. Through our unparalleled science, data, technology and laboratory network, we advance diagnostics, accelerate innovation and help address some of the world’s most important health challenges. As we shape the future of healthcare, we are leveraging advanced technologies, intelligent digital solutions and data-driven innovation across our operations to enhance how work gets done and deliver greater value to customers and patients. With our global scale and deep expertise, you’ll have the opportunity to do meaningful work, grow your career and make a real impact on people’s health around the world. Together, we’re improving health and improving lives.

Labcorp is seeking an LC-MS Chemist – Metabolism to join our team in Madison, WI.

Work Schedule: Monday - Friday 8:00 am - 5:00 pm

Job Responsibilities

• Organize and independently perform routine to moderate-level method validation activities in compliance with SOPs and regulatory guidelines (GLP/GCP).
• Execute advanced method validation tasks with guidance from a Lead Scientist.
• Apply intermediate data interpretation and analytical instrumentation skills to resolve procedural and scientific problems with minimal assistance.
• Assist in the review of reports, methods, protocols, and SOPs; maintain complete and audit-ready study documentation.
• Communicate problems, deviations, and corrective actions to Lead Scientist and/or management in a timely manner.
• Manage assigned project work, coordinating activities with team members to deliver high-quality data to internal clients on schedule.
• Collaborate effectively with colleagues across the Bioanalytical site and support cross‑functional communications with external clients.
• Train and mentor less experienced laboratory staff.
• Contribute to process improvement initiatives and participate in department‑wide quality initiatives.
• Maintain a clean, safe, and organized laboratory environment.

Minimum Qualifications

• Bachelor's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1.5 or more years of hands‑on experience with LC-MS/MS bioanalysis, including MRM‑based quantitation and method execution.
• 1.5 or more years of experience with ADME/PK assays such as liver microsomal stability, permeability assays (e.g., MDCK‑MDR1), and PK sample processing (plasma, tissue lysates).
• 1.5 or more years operating triple quadrupole mass spectrometer platforms (e.g., Waters Xevo TQS, Agilent 6400 QQQ, SCIEX 5500, and SCIEX 6500).

Preferred Qualifications

• Master's degree in Life Sciences, Chemistry, Biotechnology, or a related field.
• 1 or more years of exposure to CYP inhibition or Time‑Dependent Inhibition (TDI) assays and drug‑drug interaction (DDI) studies.
• 1 or more years of experience assisting in the development or optimization of new bioanalytical methods.

Additional Job Standards

• Proficiency with data acquisition and processing software (MassLynx, MassHunter, Analyst, or equivalent).
• Proficiency with ELN documentation, word processing, spreadsheet, and specialized analytical software.
• Strong attention to detail with demonstrated ability to generate reproducible, high‑quality bioanalytical data.
• Familiarity with Orbitrap platforms or other high‑resolution mass spectrometry systems.
• Knowledge of regulatory guidelines including FDA, EMA, and ICH bioanalytical method validation guidance.
• Experience working in a GLP/GCP‑regulated environment (CRO or pharmaceutical/biotech industry).
• Excellent written and verbal communication skills.
• Proven ability to prioritize workloads and manage time effectively in a fast‑paced laboratory environment.

Benefits

Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan. Employees regularly scheduled to work less than 20 hours, Casual, Intern, and Temporary employees are only eligible to participate in the 401(k) Plan. For more detailed information, pleaseclick here.

Labcorp Is Proud To Be An Equal Opportunity Employer

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), family or parental status, marital, civil union or domestic partnership status, sexual orientation, gender identity, gender expression, personal appearance, age, veteran status, disability, genetic information, or any other legally protected characteristic. Additionally, all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

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