Late-Stage LNP Process Development Scientist

Eurofins PSS Insourcing Solutions

Boston (MA)

On-site

USD 49,593 - 57,859

Full time

14 days+

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Benefits offered by this job

Comprehensive medical coverage

401(k) with company match

Paid vacation and holidays

Eligibility for yearly bonus

Job summary

Eurofins PSS Insourcing Solutions is seeking a laboratory professional to join their Late-Stage LNP Process Development team in Boston, MA. This full-time role will involve supporting the process development and characterization of LNP drug products. Candidates must possess a B.S. degree in a relevant field and have experience with LNP manufacturing processes.

The position offers comprehensive medical coverage, a 401(k) plan with company matching, paid vacation, and a competitive hourly wage of $36.00-$42.00.

Qualifications

3-4 years of relevant laboratory experience with B.S. or 1-2 years with M.S.
Proficiency in LNP manufacturing focusing on TFF processes.
Experience with DLS and osmolality for in-process monitoring.

Responsibilities

Support routine process development for LNP drug manufacturing.
Execute analytics including DLS and UV-quantification.
Write technical documentation and maintain lab equipment.

Skills

Bench-scale drug product manufacturing of LNPs

Mixing and tangential flow filtration (TFF)

Data analysis and troubleshooting

Strong writing and communication skills

Education

B.S. degree in chemical/biomedical engineering, chemistry, or biological sciences

M.S. degree in biological or biochemical sciences

Tools

Dynamic light scattering (DLS)

Electronic lab notebooks (e.g., Benchling)

Job description

Job Description

As a member of the Late-Stage LNP Process Development team, the candidate will be joining a team conducting laboratory studies to support the process development, process scale‑up, and process characterization of LNP clinical stage drug products. The successful candidate will have experience with LNP process development (having additional experience in tech transfer and GMP manufacturing is a plus but not required), and a desire to contribute to a team focused on establishing science‑based manufacturing solutions for complex nucleic acid‑based drug products. In this highly collaborative and cross‑functional role, the candidate will support the refinement of process control and improve process understanding for multiple programs at various stages of clinical development.

Support routine process development and process characterization activities centered around the LNP drug product manufacturing process. Batch ranges vary from 10 mg to 1 gram.
Execute routine analytics including dynamic light scattering (DLS), UV‑quantification via Ribogreen, pH, and osmolality for in‑process monitoring.
Perform experiments under limited to no supervision under subject matter expert guidance.
Organize and analyze data, interpret results, and present findings within the process development team and cross‑functionally.
Author technical documentation (SOPs, reports, protocols) as required.
Document experiments and protocols using electronic lab notebooks (e.g., Benchling).
Maintain laboratory equipment, order critical reagents, and support operational excellence activities.

Minimum Required Qualifications

B.S. degree in chemical/biomedical engineering, chemistry, or biological sciences (or related field) with 3-4 years of relevant laboratory experience. M.S. degree in biological or biochemical sciences (or related field) with 1-2 years of relevant laboratory experience.
Proficiency in bench‑scale drug product manufacturing of LNPs with a focus on mixing and tangential flow filtration (TFF) processes.
Experience with practices and equipment used in process development of nucleic acids (experience with T‑mixing and TFF is preferred).
Experience with DLS and osmolality for in‑process monitoring.
Experience working with ELN systems such as Benchling.
Experience with technical documentation (SOPs, technical reports, protocols).
Ability to follow established SOPs for routine analytics.
Ability to achieve results, keep to a timeline, and find solutions to ensure that overall project deliverables are met.
Strong attention to detail, analysis of data/reports, troubleshooting, and problem‑solving abilities.
Strong writing and communication skills with the ability to understand and communicate scientific information.
Strong organizational and time management skills.
Willingness to collaborate with cross‑functional teams.
Proactive, creative, and positive attitude.

Preferred Qualifications

Experience with UV‑quantification via Ribogreen.
Experience with GMP manufacturing practices and tech transfer operations is a plus.
Experience with statistical analysis software (e.g., JMP, Design Expert, etc.) is a plus.
Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information

The position is full-time, Monday-Friday, 8 am-5 pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply.

Benefits