IT Commercial & Medical Apps Leader

Amylyx Pharmaceuticals, Inc.; Cambridge (MA); Hybrid; USD 137,000 - 154,000; Full time

Job summary

Amylyx Pharmaceuticals, Inc. is seeking a Manager, IT Commercial and Medical Affairs Applications in Cambridge, MA.

The role partners with Commercial, Medical Affairs, Marketing and IT to deliver and optimize critical business systems, including CRM platforms, with a strong focus on regulatory compliance and data integrity. You will contribute to business analysis, project management, and system administration, while leveraging AI-powered tools to accelerate delivery and automation across the

Qualifications

• Bachelor’s degree in computer science or related field.
• 5+ years IT/business systems experience.
• 3+ years admin experience with CRM/omnichannel platforms (Salesforce, Veeva).
• Life Sciences Commercial/Marketing/Medical Ops exp preferred.
• Proficiency with AI tools and scripting; able to apply them.
• Experience delivering IT projects within change-management controls.
• Strong business analysis: requirements, process flows, specs.
• Experience in regulated environments, validation and UAT.
• Excellent communication, analytical and problem-solving skills.
• Customer service orientation and interpersonal skills.
• Self-motivated with high attention to detail.

Responsibilities

• Lead hands-on activities for delivery of Commercial and Medical app requirements.
• Document current and future-state processes, workflows, specs, and business rules.
• Manage end-to-end IT change management and enhancements.
• Identify opportunities for process optimization and automation.
• Leverage AI-powered tools to improve productivity and delivery.
• Administer and support Salesforce and Veeva Vault; user management and basic config.
• Support integration activities by defining requirements and coordinating testing.
• Contribute to vendor evaluations and RFPs with requirements and materials.
• Ensure compliance with FDA, SOX, GDPR regulatory requirements.
• Build strong cross-functional relationships across Commercial, Medical Affairs, IT.

Skills

IT business analysis

Project management

CRM administration

AI tools & automation

Process optimization

Communication

Problem solving

Attention to detail

Education

Bachelor’s degree in computer science or related field

Tools

Salesforce.com

Veeva Vault

Job description

Manager, IT Commercial and Medical AffairsApplications

Cambridge, MA

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Reporting to the Director, IT Commercial Business Partner, the Manager, IT Commercial & Medical Applications will support the delivery and ongoing optimization of Commercial and Medical technology solutions. This work combines hands-on execution with cross-functional coordination to advance critical business systems in a growing environment.

In addition to supporting initiative delivery, this individual will contribute directly to business analysis, project management, and system administration activities. Partnering closely with stakeholders across Commercial, Medical Affairs, Marketing, Patient Services, and external vendors, the Manager will help deliver solutions that meet business needs while aligning with established technology strategies, standards, and compliance requirements.

Responsibilities

• Lead hands-on activities for the delivery of Commercial and Medical application requirements, translating stakeholder needs into clear requirements and actionable deliverables.
• Document current and future-state processes, workflows, functional specifications, and business rules to support scalable and compliant system solutions.
• Manage end-to-end delivery of IT change management and enhancements, including scope, timelines, dependencies, risks, and status communications.
• Identify opportunities for process optimization and automation.
• Leverage AI-powered tools and LLMs to improve productivity and accelerate delivery.
• Administer and support commercial platforms (e.g., Salesforce, Veeva Vault), including user management, basic configuration, troubleshooting, and coordination of more complex changes with vendors.
• Support integration activities by defining requirements, assisting with testing, and coordinating across systems and teams.
• Contribute to RFP and new vendor evaluations through requirements documentation, solution analysis, and coordination of supporting materials.
• Ensure compliance with regulatory requirements, including FDA computer systems assurance, SOX, and GDPR.
• Build and maintain effective working relationships and facilitate cross-functional collaboration across Commercial, Medical Affairs, IT, and external partners

Required Qualifications

• Bachelor’s degree in computer science or related field.
• Minimum 5+years of progressive experience in IT, business systems analysis, project management, or consulting roles.
• 3+ years of administrative experience with CRM and omnichannel customer engagement platforms (e.g., Salesforce.com, Veeva).
• Experience in Commercial, Marketing, and/or Medical Operations within Life Sciences is preferred.
• Demonstrated proficiency with AI-powered tools, automation platforms, scripting technologies, and the ability to apply them effectively is preferred.
• Demonstrated ability to execute IT projects within controlled change management frameworks.
• Strong business analysis skills: requirements, process flows, and functional specifications.
• Experience supporting regulated environments, validation and User Acceptance Testing processes
• Excellent communication, analytical, and problem-solving skills.
• Strong customer service orientation and interpersonal skills
• Self-motivated with high attention to detail.

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation.
• You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

$147,000 - $165,000 USD

To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn .

Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Create a Job Alert

Interested in building your career at Amylyx Pharmaceuticals? Get future opportunities sent straight to your email.

Accepted file types: pdf, doc, docx, txt, rtf

Enter manually

Accepted file types: pdf, doc, docx, txt, rtf

Are you legally authorized to work in the United States without restriction? * Select...

Will you now or in the future require employer sponsorship or assistance to be authorized to work legally in the U.S. (including but not limited to sponsorship or assistance under H-1B, TN, O-1, E-3, F-1 OPT/STEM OPT requirements)? * Select...

Have you completed the following level of education: Bachelor's Degree? * Select...

Address *

City *

State *

Do you have experience supporting the Commercial function in Pharma/Biotech? * Select...

Do you have CRM experience? * Select...

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Amylyx Pharmaceuticals’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.