Information Security Analyst I

Arrowhead Pharmaceuticals; Madison (WI); On-site; USD 70,000 - 110,000; Full time

Job summary

Arrowhead Pharmaceuticals, Inc. in Madison, WI is seeking an Information Security Analyst to support security controls across endpoint, identity, and Microsoft 365 environments.

The role emphasizes learning, process adherence, and collaboration with senior team members to strengthen our security posture. The ideal candidate has a foundational IT background, 1+ years in information security, and hands-on experience with Microsoft Defender Portal and Intune.

Qualifications

• Bachelor's degree or equivalent practical experience in information security, IT, CS.
• 1+ years in information security or related roles.
• Experience with Microsoft Defender Portal and Intune preferred.

Responsibilities

• Monitor security alerts and escalate to senior staff as needed.
• Support endpoint security and compliance with Intune and Microsoft security tools.
• Maintain device compliance policies and security settings per standards.
• Test and validate security changes, policy updates, and endpoint configurations.
• Assist with user and device access reviews and MFA support.
• Document procedures and runbooks.
• Investigate security issues and address endpoint gaps with IT teams.
• Assist with routine reporting and remediation tracking.
• Contribute to security awareness and process improvements.
• Use PowerShell scripts to automate tasks and reporting.

Skills

InfoSec experience

MDM/MAM policies

Intune

Microsoft Defender

PowerShell

Sentinel

Secure Score

Communication skills

Analytical thinking

Education

Bachelor's degree in Information Security / IT / CS

Tools

Intune

SIEM tools

EDR platforms

Microsoft Defender Portal

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

We’re seeking an Information Security Analyst with a foundational background in IT support, system administration, or security operations and an interest in growing their career in information security. This role will support the implementation, monitoring, and maintenance of security controls across endpoint, identity, and Microsoft 365 environments. The ideal candidate is detail-oriented, eager to learn, and comfortable working with established processes, documentation, and security tools under the guidance of senior team members.

Responsibilities

• Assist with monitoring security alerts and escalated issues to senior team members as needed.
• Support endpoint security and compliance efforts within Microsoft Intune and related Microsoft security tools.
• Help maintain device compliance policies, configuration profiles, and security settings following established standards.
• Participate in testing and validation of security changes, policy updates, and endpoint configurations.
• Assist with user and device access reviews, MFA support, and identity-related security tasks.
• Help document procedures, standards, and troubleshooting steps in runbooks or internal knowledge bases.
• Work with IT teams to investigate security issues, configuration inconsistencies, and endpoint compliance gaps.
• Assist with routine reporting, tracking remediation items, and following up on assigned security tasks.
• Contribute to security awareness and continuous improvement efforts as assigned.
• Use PowerShell and/or Intune remediation scripts to automate repetitive tasks, reporting, and configuration drift checks.

Requirements

• Bachelor's degree in Information Security, Information Technology, Computer Science, or a related field, or equivalent practical experience
• 1 + years of experience in Information Security, System Administration, Help Desk or similar roles
• Exposure to MDM/MAM policies for Windows/MacOS/iOS/Android
• Demonstrated hands‑on experience administering Microsoft Defender Portal, in the following areas{{:}} Sentinel, Secure Score, Cloud Apps
• Strong analytical and problem‑solving skills with the ability to investigate alerts, interpret audit logs, and distinguish signal from noise
• Effective written and verbal communication skills, with the ability to explain technical concepts to non‑technical stakeholders
• Ability to follow established procedures, manage assigned tasks, and escalated when appropriate.

Preferred

• Microsoft certifications relevant to security and compliance
• Prior experience in the pharmaceutical, biotech, or life sciences sector
• Exposure to SIEM tools, endpoint detection and response (EDR) platforms, or identity and access management systems
• Comfortable working across functional teams including Legal, Compliance, HR, and IT, and possesses the judgment to handle sensitive data and insider risk information with appropriate discretion.
• Exposure to Intune device configurations and MDM Policies

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.