Influenza Vaccine Scientist — Virology & CVV Development

Texas Biomedical Research Institute; San Antonio (TX); Sur place; USD 85 000 - 125 000; Plein temps

Résumé du poste

Texas Biomedical Research Institute in San Antonio, TX, seeks a Biological Scientist Journeyman to advance influenza virus reverse genetics and vaccine development in a high-containment environment. You will work on generating CVVs for CDC submission and ensure quality documentation throughout the process.

The role involves GLP-compliant plasmid work, HA/NA gene construction, and viral assays in collaboration with national and international partners.

Qualifications

• Bachelor's degree in Microbiology, Molecular Biology, Virology or Cell Biology with 3+ years of research experience.
• Master's degree in relevant field is preferred and highly valued.
• Experience with GLP regulations and documentation is preferred.
• Knowledge of propagation and adaptation of influenza virus is advantageous.

Responsabilités

• Conduct laboratory techniques including aseptic cell culture, plasmid preparation, electrophoresis, enzyme digestion, cell transfection, egg inoculation and harvest, generation of vaccine stocks, and QC testing.
• Analyze molecular data related to virus replication, innate immune response, host challenge, and pathogenesis.
• Cloning or synthesizing HA and NA genes into CDC vectors and preparing high-quality plasmids in GLP-compliant conditions.
• Perform HA assays with turkey red blood cells and EID50 assays to validate GLP-CVV stocks.
• Maintain GLP standards and accurate documentation; develop SOPs in accordance with FDA GLP regulations.
• Prepare Batch Production Records and review SOPs, BPRs and study reports.

Connaissances

Virology techniques

Cell culture

Molecular biology

Animal models

Formation

Bachelor's in Microbiology

Master's in Microbiology

Description du poste

Texas Biomedical Research Institute in San Antonio, TX, seeks a Biological Scientist Journeyman to advance influenza virus reverse genetics and vaccine development in a high-containment environment. You will work on generating CVVs for CDC submission and ensure quality documentation throughout the process.

The role involves GLP-compliant plasmid work, HA/NA gene construction, and viral assays in collaboration with national and international partners.