In Vivo Scientist

Eurofins Germany BioPharma Product Testing; West Point (PA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Medical, dental, and vision coverage

Job summary

Eurofins Scientific is seeking an In Vivo Scientist to contribute to HIV discovery research. The role will focus on virus production, characterization and support of HIV discovery efforts using primary human cells and cell lines.

Responsibilities include design and execution of production workflows, data analysis, and collaboration across a research team. Strong publication history and US work authorization are preferred.

Qualifications

• Ph.D. in Biomedical Sciences, Microbiology, Immunology, Virology, or related.
• HIV research and BSL-2 lab operations with strong publication record preferred.
• Familiarity with HIV host-pathogen interactions.
• Expertise in viral propagation, concentration and characterization incl. ultracentrifugation, titer and neutralization assays.
• Molecular biology techniques including CRISPR, siRNA knockdown, transfection, site-directed mutagenesis and Western blotting.
• Experience with in vivo mouse studies, tissue harvesting and isolating viral RNA.
• Experience with ELISA.
• Proficiency with FlowJo, GraphPad Prism and SnapGene or Geneious Prime.

Responsibilities

• Lead design, execution, optimization and characterization of HIV production workflows and inventory management.
• Conduct HIV discovery research using primary human cells and immortalized cell lines.
• Perform and analyze experiments with multi-parameter flow cytometry, RT-qPCR, PCR, ELISA and MSD multiplex assays.
• Generate and characterize stable cell lines expressing proteins of interest.
• Support in vivo studies including tissue collection and ex vivo viral RNA isolation.
• Analyze and interpret data, communicate findings and contribute to project strategy.

Education

Ph.D. in Biomedical Sciences, Microbiology, Immunology, Virology, or related

Tools

FlowJo

GraphPad Prism

SnapGene

Geneious Prime

CRISPR gene editing

Job description

Cellular Molecular Pharmacology Scientist

• Full-time

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins laboratories work with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

The Eurofins network of companies is the global leader in food, environment, pharmaceutical and cosmetic product testing and in agroscience Contract Research Organisation services. It is one of the market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, advanced material sciences and in the support of clinical studies, as well as having an emerging global presence in Contract Development and Manufacturing Organisations. It also has a rapidly developing presence in highly specialised and molecular clinical diagnostic testing and in-vitro diagnostic products.

In over 30 years, Eurofins has grown from one laboratory in Nantes, France to 58,000 staff across a decentralised and entrepreneurial network of 900 laboratories in over 54 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

In 2021, Eurofins generated total revenues of EUR 6.72 billion, and has been among the best performing stocks in Europe over the past 20 years.

Role Overview

We are seeking a highly motivated In Vivo Scientist to contribute to discovery research. This position will focus on HIV research, including virus production, characterization, and support of HIV discovery efforts.

Key Responsibilities

• Lead the design, execution, optimization, and characterization of HIV production workflows. As well as inventory management.
• Conduct HIV discovery research using primary human cells (PBMCs, CD4+ T cells) and immortalized cell lines (THP-1, Jurkat, MT-4).
• Perform and analyze experiments utilizing multi-parameter flow cytometry (2 colors or more), RT-qPCR, PCR, ELISA, and MSD multiplex assays.
• Generate and characterize stable cell lines expressing proteins of interest.
• Support in vivo studies, including tissue collection and processing, and perform ex vivo viral RNA isolation from tissues and/or blood samples.
• Analyze and interpret experimental data, communicate findings, and contribute to project strategy and execution.

Qualifications

• Ph.D. in Biomedical Sciences, Microbiology, Immunology, Virology, or a related scientific discipline. Equivalent combination of a lesser degree and industry experience would also be acceptable.
• Demonstrated experience in HIV research and BSL-2 laboratory operations, with a strong HIV publication record preferred.
• Familiarity with HIV host-pathogen interactions.
• Expertise in viral propagation, concentration, and characterization techniques, including ultracentrifugation, viral titer determination, and neutralization assays.
• Hands-on experience with molecular biology techniques, including CRISPR gene editing, siRNA-mediated knockdown, transfection, site-directed mutagenesis, and Western blotting.
• Experience with in vivo mouse studies, including animal handling, tissue harvesting, and isolating viral RNA from ex vivo tissues and/or blood samples.
• Experience with ELISA.
• Proficiency with scientific data analysis and visualization software, including FlowJo, GraphPad Prism, and SnapGene or Geneious Prime.
• Strong problem-solving skills, attention to detail, and the ability to work effectively in a collaborative research environment.
• Authorization to work in the United States indefinitely without restrictions or sponsorship.

Nice to have

• Willingness to learn omics techniques, i.e. MSD multiplex assays, Nomics, Olink, 10X Genomics scRNAseq.

Position is Monday- Friday 8:00 am- 5:00 pm with overtime as needed.

Excellent full time benefits including comprehensive medical coverage, dental, and vision options.

• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

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