In Vivo Pharmacology Scientist, Translational Sciences

Altos Labs; Redwood City (CA); On-site; USD 148,000 - 220,000; Full time

Job summary

Altos Labs is seeking a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences. You will oversee the full lifecycle of in vivo pharmacology studies in support of therapeutic programs.

The role requires hands-on experience with rodent models (mice and rats), study design, data analysis, and collaboration across discovery biology, pharmacology, and DMPK. Strong emphasis on animal welfare and ethical conduct.

Qualifications

• Ph.D. in biological sciences with 3–5 years (Scientist) or 6+ years (Sr. Scientist) of industry experience.
• Extensive in vivo rodent research experience in mice and rats.
• Strong commitment to animal welfare and 3Rs.
• Excellent communication and collaboration skills.
• Ability to design, troubleshoot, and interpret complex in vivo studies.

Responsibilities

• Lead full lifecycle of in vivo pharmacology studies across multiple projects, providing in vivo pharmacology and physiology expertise from study design and model selection through dosing and in-life monitoring, tissue collection and processing, data analysis, interpretation, and reporting of results to program teams.
• Contribute to selection of pharmacodynamic and target-engagement readouts.
• Contribute to building translational strategy by leveraging in vivo research for target validation and candidate progression.
• Develop, characterize, and implement new animal models; including models of fibrosis and other age-related pathologies.
• Evaluate and implement new technologies, platforms, and best practices for in vivo research to enhance study efficiency and quality.
• Execute studies in both mice and rats, including conducting survival surgeries to establish rodent models using aseptic technique.
• Occasionally execute downstream ex vivo analyses.
• Maintain detailed documentation of all studies in the electronic lab notebook to ensure data integrity and traceability.
• Collaborate with cross-functional partners across discovery biology, pharmacology and assay sciences, DMPK, and technology development to advance therapeutic programs.
• Ensure all in vivo work meets IACUC-approved protocols and uphold the highest ethical standards in study conduct.
• Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.

Skills

In vivo pharmacology

Rodent handling

Study design

Data analysis

Scientific communication

Ethics and compliance

Education

Ph.D. in biological sciences

Tools

RNA/DNA extraction

PCR

Western blot

ELISA

Small molecule assays

Job description

Altos Labs is seeking a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences. You will oversee the full lifecycle of in vivo pharmacology studies in support of therapeutic programs.

The role requires hands-on experience with rodent models (mice and rats), study design, data analysis, and collaboration across discovery biology, pharmacology, and DMPK. Strong emphasis on animal welfare and ethical conduct.