Immunology Research Scientist I/II – Drug Discovery

Iambic; San Diego (CA); On-site; USD 113,000 - 156,000; Full time

Benefits offered by this job

Competitive pay

Company-paid healthcare

Flexible spending accounts

Life insurance

401(k) matching

Uncapped vacation

Job summary

Iambic Therapeutics is seeking a hands-on Research Scientist I/II with strong immunology training to join the Biology group in San Diego. You will design and execute in vitro and ex vivo studies that generate data for target validation, hit-to-lead, and development candidate selection, collaborating across biology, chemistry, DMPK, and computational biology teams.

The role emphasizes assay development, data integrity, and close teamwork in a fast-paced drug discovery environment at our San Diego

Qualifications

• PhD in immunology or related field with 0–4 years experience, or MS/BS with extensive experience.
• Strong knowledge of innate/adaptive immunology and signaling mechanisms.
• Hands-on experience with in vitro and ex vivo immunology using human/animal cells and tissue-derived systems.
• Experience developing cell-based assay cascades and transferring assays to CROs or HTS platforms.
• Experience supporting small-molecule discovery through screening or profiling.
• In vivo immunology/pharmacology knowledge is a plus.
• Demonstrated scientific rigor and collaborative, bench-focused mindset.

Responsibilities

• Design and execute in vitro and ex vivo assays using immune cells and tissues to measure potency and functional responses.
• Run recurring compound-profiling assays to support hit-to-lead cycles.
• Apply quantitative pharmacology and data-quality practices to analyze concentration–response relationships.
• Maintain electronic lab records and communicate results at meetings.
• Support in vivo immunology studies and readout selection; interpret PK/PD data.
• Collaborate with CROs and external partners; troubleshoot technical issues.
• Contribute to lab operations and method documentation.

Skills

Immunology

In vitro assays

Flow cytometry

Ex vivo studies

Data analysis

Experiment design

Collaboration

Drug discovery

Education

PhD in Immunology

MS in related field

Postdoctoral training

Tools

Flow cytometer

Cytokine assays

Multiplex assays

Ex vivo assay systems

Job description

Iambic Therapeutics is seeking a hands-on Research Scientist I/II with strong immunology training to join the Biology group in San Diego. You will design and execute in vitro and ex vivo studies that generate data for target validation, hit-to-lead, and development candidate selection, collaborating across biology, chemistry, DMPK, and computational biology teams.

The role emphasizes assay development, data integrity, and close teamwork in a fast-paced drug discovery environment at our San Diego