Immunology Discovery Lead - Target & Translation

Vertex Pharmaceuticals Inc (US); Seattle (WA); On-site; USD 140,000 - 210,000; Full time

Job summary

Vertex is seeking a highly motivated Discovery Immunology Principal Research Scientist to lead immunology discovery programs focused on autoimmune diseases. This on-site, laboratory-based role involves shaping strategy, identifying targets, validating mechanisms, and advancing early drug discovery in a collaborative biotech environment.

The successful candidate will design and interpret in vitro/in vivo studies, develop disease models, and mentor scientists while contributing to publications and

Qualifications

• Deep expertise in autoimmune/inflammatory immune-mediated diseases.
• Immunology assay development and cell-based testing; immune-stromal or organoid co-cultures preferred.
• Immune-cell profiling, flow cytometry, and multi-parameter analyses.
• Molecular/biochemical/cytokine and immune-signaling analyses.
• Target validation, pathway interrogation, and preclinical disease models.
• Familiarity with single-cell, genomic, proteomic, systems-immunology, or bioinformatics approaches.
• Strong publication record and scientific contributions.

Responsibilities

• Lead discovery immunology programs from target identification through mechanism-of-action studies.
• Design, oversee, and interpret in vitro, ex vivo, and in vivo studies across innate and adaptive immunity.
• Develop disease-relevant models, innovative approaches, and translational strategies.
• Collaborate with biology, translational sciences, biomarkers, and project leadership to guide programs.
• Mentor scientists and foster scientific excellence and collaboration.
• Track emerging science and communicate findings to stakeholders and leaders.

Skills

Autoimmune diseases

Immunology assays

Flow cytometry

Molecular analyses

Target validation

Single-cell/bioinformatics

Publications

Education

PhD in Immunology

Bachelor's + 10 years experience

Job description

Vertex is seeking a highly motivated Discovery Immunology Principal Research Scientist to lead immunology discovery programs focused on autoimmune diseases. This on-site, laboratory-based role involves shaping strategy, identifying targets, validating mechanisms, and advancing early drug discovery in a collaborative biotech environment.

The successful candidate will design and interpret in vitro/in vivo studies, develop disease models, and mentor scientists while contributing to publications and