Histotechnologist

Nudge Real Estate; San Francisco (CA); On-site; USD 70,000 - 90,000; Full time

Job summary

A cutting-edge technology company in San Francisco is seeking a Histotechnologist to manage histology workflows focused on rodent brain tissue. In this role, you will conduct advanced histological processing and staining, optimize imaging strategies and tissue clearing methods, and work closely with research scientists on innovative projects. Candidates should have over 3 years of histotechnology experience, proficiency in core techniques, and relevant certification. This position is essential in advancing non-invasive neurological research.

Qualifications

• 3+ years of hands-on experience in histotechnology, focused on rodent brain tissue.
• Proficiency in core histological techniques including microtomy and staining.
• High integrity and strong professional judgment required.

Responsibilities

• Perform routine and advanced histological processing of rodent brain tissue.
• Execute standard histological stains and immunohistochemistry.
• Operate and optimize tissue clearing platforms for imaging.
• Prepare samples for spatial omics platforms.

Skills

Histotechnology

Microtomy

H&E staining

Immunohistochemistry

Tissue embedding

Education

HT(ASCP) certification or equivalent

Bachelor’s degree in biology or neuroscience

Tools

Light sheet microscopy

Automated staining platforms

Job description

About Nudge

At Nudge, our mission is to develop the best technology for interfacing with the brain to improve people's lives. We're starting with an approach that we believe can help the most people the fastest, and also allow us to learn as much about the brain as possible: developing a non-invasive, ultrasound-based device that can stimulate and image the brain at high resolution and depth. This is a vertically integrated effort building cutting‑edge hardware, software, and research capabilities to create products that can benefit millions — and eventually billions — of people.

To succeed, we need to assemble world‑class teams across everything we do. We hire people who are exceptional at their craft, believe hard things are worth doing, and execute relentlessly — people who expect the highest levels of both rigor and integrity from each other.

About the role

We’re looking for a Histotechnologist to own and execute histology workflows at Nudge, focused primarily on mouse and rat brain tissue. You’ll be responsible for building the full histology pipeline: perfusion, prosection, embedding, sectioning, staining, and imaging — across both traditional and cutting‑edge techniques, to understand the mechanisms of ultrasonic neuromodulation.

As a Histotechnologist at Nudge, you will:

• Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome

• Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms

• Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole‑brain and thick‑section imaging

• Prepare cleared tissue for light‑sheet fluorescence microscopy and volumetric 3D imaging

• Operate and maintain automated sectioning and tissue processing systems

• Prepare and process samples for spatial omics platforms, including multiplexed protein imaging and spatial transcriptomics, with both RNA‑ and protein‑based tagging approaches

• Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality

• Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions

About you

• 3+ years of hands‑on experience in histotechnology, with significant time spent processing rodent brain tissue

• Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry

• Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)

• Familiarity with automated staining and sectioning platforms

• HT(ASCP) certification or equivalent training; Bachelor’s degree in biology, neuroscience, or a related field preferred

• High integrity and strong professional judgment