Histology Technologist III (3rd shift - Up to 35% shift diff)

Caris Life Sciences; Phoenix (AZ); On-site; USD 55,000 - 85,000; Full time

Job summary

Caris Life Sciences in Phoenix, AZ seeks a Histology Technologist III to support pathology with IHC, embedding, microtomy, and high-complexity staining platforms. Under supervision, you will ensure QC, proper labeling, and workflow integrity in a fast-paced laboratory.

The role requires 5+ years in IHC/histology, HT/HTL (ASCP), and accredited degree or equivalent training. Travel and occasional after-hours work are expected.

Qualifications

• 5+ years of experience in an IHC/histology laboratory.
• HT/HTL (ASCP) certification required.
• Degree from ABHES/CAAHEP accredited program or equivalent training.
• Experience with high-complexity IHC staining platforms.

Responsibilities

• Perform embedding, microtomy and high-complexity IHC staining and QC.
• Operate Ventana, Dako Auto-stainer and Dako Omnis platforms.
• Identify problems and collaborate with leadership for solutions.
• Assist in training new staff and maintain LIS documentation.

Skills

IHC

Histology

Microscopy

Quality control

Laboratory skills

Education

Bachelor's degree in medical laboratory science

HT/HTL (ASCP) certification

Tools

Ventana

Dako Omnis

Dako Auto-stainer

Job description

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives. We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting‑edge molecular science and AI, we ask ourselves every day: "What would I do if this patient were my mom?" That question drives everything we do. But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Histology Technologist III will utilize the knowledge necessary to assist pathology professionals with Immunohistochemistry (IHC), specimen processing, embedding, slide preparation, microtomy, and other high complexity procedures performed in the laboratory such as IHC staining, QC, and Grossing. The Histology Technologist III also performs other non-high complexity tasks such as IHC Lab Ops tasks. This position works under direct supervision and follows standard procedures and written instructions to accomplish assigned tasks.

Job Responsibilities

• The competency for Histology Technologist III involves Basic Histology (embedding and microtomy) as well as high complexity testing such as Ventana and Dako IHC staining and IHC QC.
• Performs routine histology tasks such as embedding and cutting, as well as high complexity tasks like QC, Grossing, loading and unloading slides on Ventana, Dako Auto-stainer and Dako Omnis staining platforms.
• Able to independently identify problems in the histology lab and collaborates with IHC Leadership to find a resolution.
• The technologist III may assist in training new employees.
• Responsible for the successful execution of laboratory protocols and standard operating procedures and undergoes training and routine competencies for applicable tasks completed within the department.
• Maintains diagnostic viability of all specimens and ensures correct patient labeling, by routinely verifying that case identification numbers match blocks and slides during each processing step; prints slides and labels as appropriate.
• Documents in laboratory logs and the laboratory information system (LIS), as directed by standard operating procedures.
• Maintains laboratory equipment and ensures that the equipment is in proper working order and notifies leadership if maintenance and/or repairs are needed.
• Demonstrates capability of identifying problems that may adversely affect test performance or reporting of tests results and takes appropriate action.
• Aides in organization success by learning special tasks such as auditing and/or cross-departmental training (Digital Pathology Image QC, ACC Video Receipt/Trash QC, Lab Ops ACC1, and PA Dissection).
• Maintains performance consistency in all trained areas.
• Assists as needed to perform other related duties and special projects to support the laboratory, as required.
• Accepts other duties as assigned.

Required Qualifications

• 5+ years of experience in an IHC/histology laboratory.
• Demonstrates strong technical skills.
• HT/HTL (ASCP) certification.
• Must meet high complexity requirements: A bachelor's degree in a chemical, biological, clinical or medical laboratory science, or medical technology from an accredited institution OR Associate degree in a laboratory science or medical laboratory technology from an accredited institution OR At least 60 semester hours, or equivalent, from an accredited institution that, at a minimum, includes either: 24 semester hours of medical laboratory technology courses OR 24 semester hours of science courses that include: 6 semester hours of chemistry; 6 semester hours of biology; AND 12 semester hours of chemistry, biology, or medical laboratory technology in any combination AND Completion of a clinical laboratory training program (this training may be included in the 60 semester hours listed above) Approved or accredited by the: ABHES (Accrediting Bureau of Health Education Schools) CAAHEP (Commission on Accreditation of Allied Health Education Programs) OR At least 3 months of documented laboratory training in IHC/histology high-complexity testing.

Preferred Qualifications

• QIHC is strongly advised.

Physical Demands

Will work at a computer some of the time as well as need to keep inventory and ordering records requiring the use of copiers, fax machines, and PDF scanners. Visual acuity and analytical skill to distinguish fine detail and ability to pass a visual color discrimination test. Manual dexterity to use common laboratory equipment and perform sterile techniques as required. Must possess ability to sit and/or stand for long periods of time. Must possess ability to perform repetitive motion. Ability to lift up to 50 pounds. May have exposure to high noise levels in the data center, fumes, and bio-hazardous material in the lab environment. Exposure to formaldehyde, xylene, DAB, and alcohol which emit fumes. The formaldehyde, xylene, and DAB are carcinogenic. May be required to handle bloodborne pathogens and general laboratory reagents. Must possess ability to use a microscope for extended periods of time. May have exposure to extreme temperatures, high noise levels, fumes, and biohazardous material/chemicals including formalin in the lab environment.

Training

All job specific, safety, and compliance training are assigned based on the job functions associated with this employee.

Other

This position requires periodic travel and some evenings, weekends and/or holidays.

Conditions of Employment

Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification. This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

Caris Life Sciences is a leading innovator in molecular science and artificial intelligence focused on fulfilling the promise of precision medicine through quality and innovation. Caris is committed to quality and excellence at our state-of-the‑art laboratories. Learn more about our tissue lab and the advanced technologies that are helping improve the lives of cancer patients.