Histology Technician or Histotechnologist (HT/HTL) - Anatomic Pathology

Mayo Career Site UK; Rochester (MN); On-site; USD 60,000 - 80,000; Full time

Job summary

Mayo Clinic in Rochester, MN is seeking Histology Technicians and Histotechnologists (HT/HTL) to join a dynamic Anatomic Pathology team across multiple specialty labs.

You will perform embedding, microtomy, staining, IHC, and related techniques to prepare high-quality slides for diagnostic review. The role emphasizes accuracy, collaboration with pathologists, and commitment to patient care.

Candidates may progress within subspecialties; visa sponsorship is not available.

Qualifications

• Histology-focused role in anatomic pathology.
• Experience with embedding, microtomy and specialized stains is preferred.
• IHC and in situ technologies familiarity is a plus.

Responsibilities

• Embed tissue specimens for sectioning.
• Perform microtomy to produce high-quality slides.
• Carry out paraffin and cryostat sectioning.
• Apply routine and special stains as required.
• Assist with IHC staining and related techniques.
• Support training of students and new staff.

Skills

Histology

Microtomy

IHC

Staining

Embedding

Cryotomy

Tools

Microscope

Job description

Mayo Clinic is seeking Histology Technicians and Histotechnologists (HT/HTL) to join a dynamic and collaborative team within Anatomic Pathology. Opportunities are available across multiple specialized laboratory areas, including:

• Histology
• Frozen Section/Surgical Pathology
• Immunohistochemistry (IHC)
• Renal Pathology

Each lab is offering unique workflows, techniques, and clinical impact.

The Anatomic Pathology Laboratories at Mayo Clinic process a high volume of complex specimens, including hundreds of thousands of paraffin-embedded blocks and over one million slides annually. Specimens include surgical, autopsy, and research material. Our laboratories take pride in contributing to accurate patient diagnoses and advancing scientific knowledge through collaboration with pathologists, clinicians, and research investigators.

Visit theClinical Labs career sitetowatch a brief video of Dane discussing a life-changing career in Histology at Mayo Clinic.

As an HT/HTL, you will play a critical role in preparing high-quality slides for pathologist review. Responsibilities may include embedding, microtomy, cryotomy, special staining, immunohistochemical techniques, and handling of fresh and complex specimens. The work requires attention to detail, adaptability, and a commitment to quality and patient care.

In addition, you will:

• Support training and onboarding of students and new employees
• Collaborate across multidisciplinary teams to ensure timely and accurate results
• Contribute to a respectful, inclusive, and team-oriented work environment
• Adapt to the unique demands and workflows of different subspecialty laboratories

Mayo Clinic offers extensive opportunities for professional growth and career advancement within Anatomic Pathology. Whether you are interested in developing technical expertise across multiple lab areas or specializing in a particular discipline, this role provides a strong foundation for long-term career development.

Don’t miss the opportunity to be part of a team dedicated to excellence in patient care, innovation, and laboratory medicine.

Histology Technician / Histotechnologist (HT/HTL)

As a Histology Technician or Histotechnologist, you will perform a variety of technical procedures to prepare high-quality microscopic slide preparations used by pathologists for diagnostic and prognostic evaluation.

These procedures may include:

• Specimen accessioning and identification
• Specimen processing and embedding
• Microtomy techniques, including:
  • Paraffin
  • Frozen (cryotomy)
  • Plastic sections
• Routine Hematoxylin and Eosin (H&E) staining
• Special stains
• Immunofluorescence
• Immunohistochemical (IHC) staining
• In situ hybridization

*Individuals hired to this position are required to complete 2 years in this position before becoming eligible to apply to other positions within Mayo Clinic.

**These positions are ineligible for visa sponsorship. Also, Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program