High-throughput data generation to advance ML design

Inceptive; Palo Alto (CA); On-site; USD 135,000 - 240,000; Full time

Benefits offered by this job

30 days paid vacation

Comprehensive health insurance

Quarterly retreats

Learning & Development budget

Job summary

A biotechnology firm in Palo Alto seeks an experienced individual to lead high-throughput data generation for machine learning applications in the design of therapeutic molecules. This role requires collaboration with various experts to optimize experimental assays and analyze biological data. Candidates should have a PhD with extensive experience in molecular biology and strong programming skills. Competitive salary and benefits are offered, including 30 vacation days and remote work options.

Qualifications

• 4+ years of post-PhD experience in industry or research.
• Ability to generate biological data above state-of-the-art.
• Must work in US lab location.

Responsibilities

• Develop high-throughput assays to measure sequence libraries.
• Collaborate with diverse team members for experimental design.
• Analyze and communicate data for AI-based molecular design.

Skills

Problem-solving

Scientific programming in Python

Knowledge of molecular biology

Experience with multiplexed assays

Data analysis of sequencing platforms

Education

PhD in a relevant field

Tools

Python

Illumina

Oxford Nanopore

Pac Bio

Job description

High-throughput data generation to advance ML design

At Inceptive, you will drive development forward that could help billions of people. To accomplish this, you will be part of a collaborative, antedisciplinary team building our biological software.

Our AI models learn to generate therapeutic molecules with improved properties by training on natural and experimentally-derived data. Acquiring data relevant to function at scale is a critical step in maximizing the performance of our models. We think broadly about the type and scale of data necessary to improve our models, then identify or invent the methods needed to acquire that data.

You will be responsible for the development and deployment of novel high-throughput assays to measure various properties of large sequence libraries. You will use a data-driven approach to optimize assays and apply chemical and biological insights to maximize the utility of information collected. You will apply this data to efficiently improve design of therapeutic molecules in close collaboration with biologists, ML and data engineers, and translational experts.

Your Mission, should you choose to accept it

• Embody our vision of an antedisciplinary environment and embrace learning about areas outside of your traditional area of expertise
• Collaborate with team members from diverse backgrounds to create experiments that creatively leverage biology and computation
• Develop and execute pooled assays to measure sequence-to-function in vitro, in cells, and in vivo
• Generate, analyze, and communicate data that maximally impacts AI-based molecular design

Qualifications

• PhD and 4+ years of post-PhD experience (e.g., startup, industry, or research)
• Problem-solver who combines deep knowledge of experimental methods with quantitative intuition to generate biological data at and beyond the state-of-the-art
• Solid foundation in theory and techniques of molecular and cellular biology
• History of building highly multiplexed assays to generate rich datasets from mammalian cells, such as large functional screens or single-cell ‘omics
• Scientific programming (preferably in Python), including analysis and visualization of complex data
• Availability to work with team members across US and Europe, with meetings starting at 8am PT
• Readiness to travel several times a year for company retreats and business events
• We value in-person collaboration and expect candidates to work at our lab location

Preferred skills

• Experience with mammalian synthetic biology, particularly for cell therapy applications
• Knowledge of RNA biology, biochemistry, and biologics drug development
• Strong understanding of next-generation sequencing platforms (Illumina, Oxford Nanopore, Pac Bio), including library preparation and data analysis
• Experience generating and analyzing large ‘omics datasets, via sequencing and/or mass spectrometry

Compensation

$135K – $240K + Bonus + Equity

What we offer

• A competitive compensation package
• 30 days paid vacation per year
• Comprehensive health insurance and 401K with company match for US based Beginners, with comparable benefits for those based in other countries
• Quarterly company-wide retreats
• Monthly wellness benefit
• Budget for multiple visits per year to our offices in Berlin, Palo Alto or Switzerland
• Learning & Development budget to attend conferences, take courses, or otherwise invest in your professional growth, as well as access to the Learning & Development platform EdX and Hone
• A buddy to help you get settled

*Varies by country

At Inceptive, we are creating tools to develop increasingly powerful biological software for the rational design of novel, broadly accessible medicines and biotechnologies previously out of reach. Our team brings together vast expertise in molecular biology, machine learning, and software engineering, and we are all working towards becoming antedisciplinary, meaning we deepen the knowledge we have in our area of expertise while also expanding our knowledge of completely new fields.

We approach our goals with a Beginner's mind, humbly and with fresh eyes, and aim to become the pioneers of a new discipline rooted in biology as much as in deep learning, whose impact will be realized together with out-of-the-box thinkers in business and entrepreneurship, defying established categorizations. We are building a company culture centered around growth, learning, and discovery. We believe in humility and open-mindedness in how we approach each other, as well as problems we don't yet have solutions for.

It is the policy of Inceptive to ensure equal employment opportunity without discrimination or harassment on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, age, disability, marital status, citizenship, national origin, genetic information, or any other characteristic protected by law. Inceptive prohibits any such discrimination or harassment.

Inceptive is also committed to welcoming and providing accommodations to people with disabilities. Please let us know if you need any accommodations throughout your application process.