High Throughput Biology Research Scientist

Vertex Pharmaceuticals LLC; Boston (MA); On-site; USD 106,000 - 158,000; Full time

Job summary

Vertex Pharmaceuticals is seeking a Research Scientist for the High Throughput Human Biology group to develop and implement innovative human biology assays that support discovery programs. The role combines cellular and molecular biology, automation, and data analysis to create scalable, high-throughput workflows and robust solutions.

You will work across disciplines, apply AI-enabled tools to improve efficiency, and advance projects from concept to implementation while contributing to rigorous

Qualifications

• PhD in a relevant scientific discipline with 0-3 years of experience.
• Strong independence and drive to impact project progression.
• Creativity in biological assay development and data analysis.
• Foundational molecular/cell biology in multi-well formats and assays.
• Proficiency in Python, R or MATLAB for data analysis.
• Experience collaborating in cross-functional teams and communicating clearly.

Responsibilities

• Develop, optimize, and implement high-throughput human biology assays across programs.
• Build automation workflows using robotics and high-throughput liquid handling.
• Analyze complex datasets and translate findings into actionable recommendations.
• Troubleshoot assays and automation; drive improvements in throughput and quality.
• Identify scientific needs and develop solutions from concept to prototyping.
• Evaluate emerging technologies and apply AI-enabled workflows.
• Represent the group in collaborative teams and maintain rigorous records.

Skills

Python

R

MATLAB

Education

PhD in a relevant scientific discipline

Tools

Laboratory automation

Job description

Job Description

Role Summary

The High Throughput Human Biology group is seeking a highly motivated Research Scientist to support discovery programs through the development and implementation of innovative human biology assays. Working in a collaborative, multidisciplinary environment, the successful candidate will draw on expertise in cellular and molecular biology, laboratory automation, and data analysis to develop in vitro assays spanning multiple levels of biological complexity and define their application within high-throughput screening strategies. The successful candidate will also evaluate and incorporate emerging technologies, establish scalable experimental workflows, and partner across disciplines to translate scientific needs into robust solutions. They will leverage AI-enabled tools to improve workflow efficiency, accelerate experimental iteration, and support data-driven project decisions.

The ideal candidate will bring strong hands-on laboratory skills, scientific and technical creativity, and the ability to independently advance projects from concept through implementation.

Key Responsibilities

• Develop, optimize, and implement high-throughput human biology assays to address key questions or challenges in discovery biology across multiple programs
• Build integrated automation workflows for cellular and biochemical assays leveraging robotics, high-throughput liquid handling, and custom computational solutions
• Execute screening and follow-up studies, analyze complex datasets, and translate findings into actionable recommendations for project teams
• Troubleshoot assay and automation performance and drive continuous improvements in throughput, data quality, and operational reliability
• Identify unmet scientific needs relevant to our research areas and develop solutions from conceptualization through prototyping and implementation
• Evaluate emerging technologies and apply promising solutions to internal programs
• Represent the High Throughput Human Biology group as part of highly collaborative, interdisciplinary teams, communicate results clearly and maintain rigorous, reproducible records

Required Qualifications

• PhD in a relevant scientific discipline with 0-3 years of relevant experience
• Scientifically curious, driven and independent, motivated by making impact to project progression
• Demonstrated creativity in biological assay development
• Foundational molecular biology and cell biology laboratory experience in multi-well plate formats, including complex human cellular assays, immunoassays, qPCR, high-content imaging, and other relevant functional and target engagement assays
• Proficiency in relevant coding languages, such as Python, R or MATLAB
• Proven track record of success working in collaborative, multi-disciplinary teams
• Excellent written and verbal communication skills

Preferred Qualifications

• Hands-on experience with laboratory automation, automated liquid handling, or integrated instrumentation strongly preferred
• Experience developing or deploying AI-enabled scientific and computational workflows strongly preferred
• A record of building and applying useful tools, prototypes, methods, or process improvements
• Ability to multi-task and prioritize effectively across involvement in multiple projects

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range

$105,600 - $158,400

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On-Site Designated

Flex Eligibility Status

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and ma