Head, Oncology Clinical Development - ADCs

GSK; Upper Providence (Delaware County); On-site; USD 242,000 - 322,000; Full time

Job summary

GSK seeks a senior leader to own end-to-end clinical development for oncology assets, spanning early to late-phase trials, regulatory readiness, and initial market launch.

The role.requires directing strategy across disease areas, coordinating across research, medical, regulatory, and commercial teams, and engaging external boards to guide portfolio decisions.

Qualifications

• Senior clinical and scientific leadership across early- and late-phase oncology drug development.
• Ability to translate science into differentiated clinical development strategies.
• Experience operating at portfolio level with asset-level rigor and accountability.
• Credibility representing Clinical Development at senior governance forums.
• Advanced cross-functional and matrix leadership with a connector mindset.
• Openness to AI/ML and innovative development approaches.

Responsibilities

• Accountable for end-to-end clinical development of MOA-focused multi-tumor assets including registrational trials, regulatory approvals, and initial market launch.
• Shape and drive scientific and clinical development strategy aligned with portfolio priorities.
• Lead governance, external engagements, and scientific advisory boards to inform strategy and decisions.

Skills

Senior clinical leadership

Oncology drug development

Cross-functional leadership

Strategic portfolio planning

AI/ML in trial design

Job description

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029 .

The Head, Oncology Clinical Development- ADCs, will report to the SVP, Head of Oncology Clinical Development. The role holder will be accountable for the design and implementation of the clinical development strategy across a particular asset across multiple tumor types spanning early- and late-phase development. This includes the strategic clinical positioning of the asset, combinations, and associated clinical development plans.

This role requires an experienced, cross-matrix senior leader capable of implementing and executing an integrated clinical strategy in support of the successful clinical development, translational research, regulatory filing and initial market launch of a growing portfolio of innovative and transformational Oncology agents.

Key Responsibilities & Accountabilities:

Clinical Development Strategy & Portfolio Leadership

• Accountable for end‑to‑end clinical development of an MOA-focused, multi‑tumor asset, including registrational trials, regulatory approval, and initial market launch, ensuring scientific rigor, speed, and quality of execution.
• Shape and drive the scientific and clinical development strategy for the asset and disease areas, aligned with Oncology Tumor Team strategy and broader Oncology portfolio priorities.
• Evaluate, champion, and enable the use of novel approaches (e.g., AI/ML, innovative trial designs, external and real‑world data sources) where they add clear scientific, operational, or decision‑making value to clinical development.

Program Oversight, Governance & Visibility

• Provide oversight and connectedness across the asset program, maintaining visibility to progress, risks, dependencies, and trade‑offs across the Oncology portfolio.
• Serve as the default senior clinical representative at key governance forums (e.g., DRB, PIB, program and portfolio governance) for the asset, ensuring strong clinical leadership, continuity, and high‑quality decision‑making.
• Represent the Oncology Clinical Development organization internally and externally, including presenting at high‑impact forums such as congress all‑hands, senior leadership reviews, and advisory boards.
• Lead scientific advisory boards and other external engagements to inform asset strategy, competitive positioning, and portfolio decisions, incorporating emerging science and external expert insight.

Cross‑Functional Leadership & Connector Role

• Act as a senior connector across functions, partnering closely with Oncology Research, Precision Medicine/Companion Diagnostics, Medical Affairs, Commercial, Competitive Intelligence, and Global Product Strategy to drive integrated development and lifecycle planning.
• Drive asset alignment across research, development, and commercialization planning, and ensuring cohesive execution against shared objectives.
• Build and sustain strong internal and external partnerships to accelerate decision‑making, resolve complexity, and optimize development outcomes in a matrixed environment.

Culture & Capability Building

• Foster a culture of empowerment, scientific excellence, inclusion, and collaboration, aligned with OneOncology values, while modeling strong, visible leadership.
• Actively remove organizational barriers and enable teams to operate effectively and autonomously within a complex, global matrix environment.

Standards, Processes & Continuous Improvement

• Contribute to the establishment and continuous evolution of clinical development standards, processes, and best practices across Oncology, ensuring consistency, quality, and regulatory readiness.
• Ensure timely access to relevant external scientific and competitive intelligence (e.g., congress data, emerging science, competitor activity) to inform clinical development decisions and portfolio strategy.

Skills & Capabilities

• Senior clinical and scientific leadership in early‑and late‑phase oncology drug development, including FTIH through registrational trials and launch readiness.
• Strong ability to translate science and translational insight into differentiated clinical development strategies across disease areas and portfolios.
• Proven capability to operate at portfolio level, balancing priorities, risk, and resources while maintaining asset‑level rigor and accountability.
• Credibility and effectiveness representing Clinical Development at senior governance forums, with strong executive presence and influence.
• Advanced cross‑functional and matrix leadership skills, with a natural connector mindset across research, development, medical, commercial, and precision medicine partners.
• Openness to and fluency with innovative development approaches (e.g., AI