Head, Oncology Clinical Development - ADCs

GlaxoSmithKline; United States; Hybrid; USD 242,000 - 404,000; Full time

Benefits offered by this job

Annual bonus

Health insurance

Retirement benefits

Paid leave

Hybrid work

Job summary

GlaxoSmithKline seeks a Head of Oncology Clinical Development- ADCs to oversee end-to-end clinical strategy for a multi-tumor asset, spanning early to launch. The role reports to the SVP and requires strong leadership across a cross-functional matrix in a global context.

The position will coordinate with Oncology Research, Medical Affairs, Commercial, and Global Product Strategy, and may require on-site work at major sites with hybrid arrangements.

Qualifications

• MD/MBBS or international equivalent is required.
• Proven oncology drug development experience from early to launch readiness.
• Experience leading global cross-functional teams in complex matrix environments.

Responsibilities

• Lead end-to-end clinical development for MOA-focused, multi-tumor asset, incl. registrational trials and launch.
• Shape the asset's scientific and clinical development strategy across disease areas.
• Champion novel approaches (AI/ML, innovative designs, external data) where value is clear.

Skills

Senior clinical leadership

Oncology drug development

Cross-functional leadership

Executive presence

AI/ML in development

Strategic portfolio management

Education

MD/MBBS/MBChB or international equivalent

Job description

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029 .

The Head, Oncology Clinical Development- ADCs, will report to the SVP, Head of Oncology Clinical Development. The role holder will be accountable for the design and implementation of the clinical development strategy across a particular asset across multiple tumor types spanning early- and late-phase development. This includes the strategic clinical positioning of the asset, combinations, and associated clinical development plans.

This role requires an experienced, cross-matrix senior leader capable of implementing and executing an integrated clinical strategy in support of the successful clinical development, translational research, regulatory filing and initial market launch of a growing portfolio of innovative and transformational Oncology agents.

Key Responsibilities & Accountabilities:

• Accountable for end-to-end clinical development of an MOA-focused, multi-tumor asset, including registrational trials, regulatory approval, and initial market launch, ensuring scientific rigour, speed, and quality of execution.
• Shape and drive the scientific and clinical development strategy for the asset and disease areas, aligned with Oncology Tumor Team strategy and broader Oncology portfolio priorities.
• Evaluate, champion, and enable the use of novel approaches (e.g., AI/ML, innovative trial designs, external and real-world data sources) where they add clear scientific, operational, or decision-making value to clinical development.

• Provide oversight and connectedness across the asset program, maintaining visibility to progress, risks, dependencies, and trade-offs across the Oncology portfolio.
• Serve as the default senior clinical representative at key governance forums (e.g., DRB, PIB, program and portfolio governance) for the asset, ensuring strong clinical leadership, continuity, and high-quality decision-making.
• Represent the Oncology Clinical Development organization internally and externally, including presenting at high-impact forums such as congress all-hands, senior leadership reviews, and advisory boards.
• Lead scientific advisory boards and other external engagements to inform asset strategy, competitive positioning, and portfolio decisions, incorporating emerging science and external expert insight.

• Act as a senior connector across functions, partnering closely with Oncology Research, Precision Medicine/Companion Diagnostics, Medical Affairs, Commercial, Competitive Intelligence, and Global Product Strategy to drive integrated development and lifecycle planning.
• Drive asset alignment across research, development, and commercialization planning, and ensuring cohesive execution against shared objectives.
• Build and sustain strong internal and external partnerships to accelerate decision-making, resolve complexity, and optimize development outcomes in a matrixed environment.

• Foster a culture of empowerment, scientific excellence, inclusion, and collaboration, aligned with OneOncology values, while modeling strong, visible leadership.
• Actively remove organisational barriers and enable teams to operate effectively and autonomously within a complex, global matrix environment.

• Contribute to the establishment and continuous evolution of clinical development standards, processes, and best practices across Oncology, ensuring consistency, quality, and regulatory readiness.
• Ensure timely access to relevant external scientific and competitive intelligence (e.g., congress data, emerging science, competitor activity) to inform clinical development decisions and portfolio strategy.

Skills & Capabilities

• Senior clinical and scientific leadership in early- and late-phase oncology drug development, including FTIH through registrational trials and launch readiness.
• Strong ability to translate science and translational insight into differentiated clinical development strategies across disease areas and portfolios.
• Proven capability to operate at portfolio level, balancing priorities, risk, and resources while maintaining asset-level rigour and accountability.
• Credibility and effectiveness representing Clinical Development at senior governance forums, with strong executive presence and influence.
• Advanced cross-functional and matrix leadership skills, with a natural connector mindset across research, development, medical, commercial, and precision medicine partners.
• Openness to and fluency with innovative development approaches (e.g., AI/ML, novel trial designs, external and real-world data) where they add value.
• Commitment to fostering a culture of scientific excellence, empowerment, inclusion, and continuous improvement in a complex global environment.

PLEASE NOTE:

This career opportunity offers hybrid working and requires an on-site office presence (minimum of two days a week) at one of GSK's UK (Stevenage or London HQ); US (Collegeville, PA or Waltham, MA) sites; or Switzerland (Zug).

Basic Qualifications:

• Medical degree (MD, MBBS, MBChB or international equivalent) is required.
• Board certification/eligibility or registration in a primary or medical specialty.
• Oncology drug development experience in the pharmaceutical industry.
• Leadership experience of early- and focused late-phase oncology development programs from first-in-human through registrational studies and launch readiness.
• Experience leading Antibody Drug Conjugate or other targeted oncology development programs.
• Experience holding accountability for asset-level or portfolio-level clinical development strategy, governance, and execution.
• Experience interacting with global health authorities and supporting regulatory submissions and approvals.
• Experience leading global cross-functional teams in complex matrix environments.

Preferred Qualifications:

• Board certification/eligibility or registration in medical oncology, hematology/oncology
• Strong experience in governance leadership, scientific narrative ownership, portfolio influence, and executive-level decision-making.
• Experience in translational research, including the application of translational science to inform clinical development strategies and decision-making.
• Experience utilizing innovative development approaches, including advanced analytics, AI/ML, real-world evidence, or novel trial design

Skills

Clinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction

If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $242,250 to $403,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [e-mail]

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/