Head of Global Manufacturing Science & Technology

BioNJ Inc.; Bridgewater (MA); On-site; USD 250,000 - 450,000; Full time

Job summary

Legend Biotech, based in Bridgewater, NJ, seeks a Head of Global Manufacturing Science & Technology (MSAT) to lead enterprise technical strategy across late-stage development through commercial manufacturing and lifecycle management. You will drive process characterization, validation, transfer, and continuous improvement to ensure robust, scalable, and capable manufacturing operations in a global network.

The role requires an advanced degree with 20+ years in MSAT or related biopharma fields,

Qualifications

• Advanced degree, preferably PhD in Chemical Engineering, Biological Sciences, or Pharmaceutical Sciences.
• 20+ years of progressive MSAT, process development, or related biopharma leadership.
• Global MSAT leadership experience for commercial biopharma products.
• Expertise in process characterization, validation, CPV, process optimization, and lifecycle management.
• Ability to lead complex decisions across R&D, CMC, Manufacturing, Quality, Regulatory, and Supply Chain.

Responsibilities

• Define and execute the global MSAT strategy and operating model.
• Establish global technical standards, capabilities, and governance for manufacturing.
• Serve as senior technical authority for process capability, robustness, and scalability.
• Own strategy for process characterization, validation, CPV, and monitoring.
• Drive continuous improvement to improve yield, capacity, throughput, and cost efficiency.
• Lead technology transfer and manufacturing readiness from development to commercial operations.
• Ensure transfer of knowledge, control strategies, and capabilities into networks.
• Provide input to major network, capacity, and commercialization decisions.
• Lead lifecycle management, scale-up/scale-out, and site transfers.
• Leverage data science, analytics, and digital manufacturing to improve performance.
• Build and lead a global MSAT organization with strong technical depth.

Skills

Executive leadership

Global MSAT leadership

Strategic thinking

Data-driven decision making

Cross-functional influence

Process optimization

Education

PhD in Chemical Engineering

PhD in Biological Sciences

PhD in Pharmaceutical Sciences

Job description

Legend Biotech is seeking a Head of Global Manufacturing Science & Technology as part of the Manufacturing Science & Technology team based in Bridgewater, NJ.

Role Overview

The Head of Global Manufacturing Science & Technology (MSAT) is the enterprise technical leader responsible for ensuring the robustness, scalability, capability, and continuous improvement of manufacturing processes across the product lifecycle. The role establishes the global MSAT strategy and provides technical leadership from late-stage development and technology transfer through commercial manufacturing and lifecycle management. The Head of Global Manufacturing Science & Technology ensures that manufacturing processes are scientifically understood, technically capable, operationally robust, scalable, and continuously improved to support reliable supply, product quality, patient needs, and business growth.

Key Responsibilities

Global MSAT Strategy & Technical Leadership

• Define and execute the global MSAT strategy and operating model aligned with business, portfolio, and manufacturing priorities.


• Establish global technical standards, capabilities, and governance for manufacturing processes across internal and external sites.


• Serve as the senior technical authority for process capability, robustness, scalability, and manufacturing performance.

Process Technology & Manufacturing Performance

• Own the technical strategy for process characterization, validation, process capability, continued process verification, and process monitoring.


• Drive consistency and systematic improvement of manufacturing processes to increase yield, reliability, capacity, throughput, consistency, and cost efficiency.


• Provide technical leadership for manufacturing investigations, process deviations, and recurring performance issues.


• Establish science- and data-based approaches to identify process risks and proactively improve manufacturing performance.

Technology Transfer & Commercialization

• Provide MSAT leadership for technology transfer and manufacturing readiness from development into commercial operations.


• Ensure effective transfer of process knowledge, control strategies, technical standards, and manufacturing capabilities into internal and external manufacturing networks.


• Partner with CMC and R&D to ensure development programs are designed for commercial scalability, manufacturability, and process robustness.


• Provide technical input to major manufacturing network, capacity, and commercialization decisions.

Lifecycle Management & Continuous Improvement

• Own the MSAT strategy for the technical lifecycle of commercial products, including process improvements, scale-up/scale-out, site transfers, capacity expansion, and manufacturing optimization.


• Identify and prioritize opportunities to improve quality, yield, throughput, cost, cycle time, and supply resilience.


• Lead implementation of advanced process technologies, automation, modeling, analytics, and digital manufacturing capabilities.


• Ensure manufacturing knowledge and process data are systematically leveraged to drive continuous improvement.

Manufacturing & Global Network

• Provide technical leadership, support and governance for MSAT activities at internal sites, CMOs/CDMOs and other external manufacturing partners.


• Ensure consistent technical standards, process understanding, technology transfer, and lifecycle management across the global manufacturing network.


• Partner with Manufacturing leadership to resolve technical, process, and performance issues.

Innovation, Digital & Advanced Manufacturing

• Establish the strategic roadmap for advanced manufacturing technologies, automation, digital manufacturing, process analytics, and data science.


• Accelerate adoption of emerging technologies that improve manufacturing control, predictability, flexibility, and efficiency.


• Promote the use of data-driven and predictive approaches to enhance process understanding and manufacturing performance.

Executive Leadership & Organization

• Build and lead a high-performing global MSAT organization with the technical depth and capabilities required to support a growing pipeline and commercial portfolio.


• Develop organizational capabilities, talent, succession, and technical leadership across the global manufacturing network.


• Serve as a senior member of the Global Manufacturing & Supply Leadership Team, contributing to manufacturing strategy, investment decisions, portfolio priorities, and supply resilience.


• Act as a trusted technical advisor to senior leadership on major manufacturing, technology, process, and investment decisions.


• Represent the company with strategic partners, regulators, industry organizations, and external technical forums.

Requirements

• Advanced degree, preferably PhD in Chemical Engineering, Biological Sciences, Pharmaceutical Sciences, or related discipline.


• 20+ years of progressive experience in MSAT, process development, manufacturing science, technical operations, or related biopharmaceutical functions, including significant global leadership experience.


• Proven global experience leading MSAT for commercial biopharmaceutical products, preferably including cell therapy, gene therapy, or other advanced modalities.


• Strong expertise in process characterization, validation, technology transfer, CPV, process optimization, manufacturing technology, and lifecycle management.


• Proven ability to lead complex technical decisions across R&D, CMC, Manufacturing, Quality, Regulatory, Engineering, and Supply Chain.


• Enterprise technical leadership with strong business judgment.


• Strong strategic thinking combined with technical depth.


• Executive presence and ability to influence across functions and organizational boundaries.


• Data-driven, scientifically rigorous, and highly pragmatic.


• Strong innovation and continuous improvement mindset.


• Develops people, builds capabilities, and creates a culture of technical excellence, accountability, and innovation.

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in-vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

• These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

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