Global Medical Director, Clinical Development (Gene Editing)

Editas; Cambridge (MA); On-site; USD 345,000 - 375,000; Full time

Benefits offered by this job

Health insurance

401(k) plan

Tuition reimbursement

Paid time off

Job summary

Editas Medicine is seeking a Senior Medical Director, Clinical Development to provide medical, scientific, and operational leadership for genetic disease and gene-editing programs. You will design and oversee global trials, partnering with R&D and the CMO to drive early development decisions and portfolio strategy.

Ideal candidates bring MD/MD-PhD, 10+ years in clinical R&D, and proven ability to lead cross-functional teams, manage partnerships, and travel to global sites.

Qualifications

• MD or MD/PhD with training in cardiovascular diseases, internal medicine, rare disease, or related fields.
• 10+ years of industry experience in clinical research and development, including leadership of early-stage cardiovascular disease and/or rare disease programs.
• Experience designing and executing global clinical trials; gene-editing/ gene therapy exposure is a plus.
• Hands-on experience overseeing trials with CROs, investigators, and hospital partners.
• Willingness to travel to oversee global trials.
• Strong understanding of trial methodology, translational science, safety monitoring, and regulatory pathways.
• Proven ability to work in matrixed teams and influence across stakeholders.
• Excellent written and verbal communication, including presentations to regulators and governance bodies.
• Strategic, pragmatic, and thrives in a high-growth biotech environment.
• Strong network of clinical investigators and collaborators worldwide.

Responsibilities

• Lead design, medical oversight, and execution of clinical development strategies for gene-editing programs (e.g., EDIT-401) with early development focus.
• Serve as clinical program lead, ensuring high-quality execution and data integrity.
• Integrate biomarker strategy, safety monitoring, and indication rationale with R&D.
• Develop and refine clinical development plans and protocols aligned with regulatory expectations.
• Prepare clinical documents for regulatory submissions (IND, CTA, NDA/BLA) with medical rationale.
• Collaborate with regulatory affairs and regional experts for global readiness.
• Coordinate with Clinical Operations, Regulatory, PM, CMC, Analytics, and Commercial teams for integrated planning.
• Partner with Research for indication selection and biomarker development.
• Provide clinical leadership in risk assessments, data reviews, and governance forums.
• Build networks with global investigators, KOLs, and patient advocacy groups.
• Lead or support scientific advisory boards, investigator meetings, and data reviews.
• Represent the company at scientific conferences and in manuscripts and abstracts.

Education

MD or MD/PhD with cardiovascular/rare disease training

Job description

Editas Medicine is seeking a Senior Medical Director, Clinical Development to provide medical, scientific, and operational leadership for genetic disease and gene-editing programs. You will design and oversee global trials, partnering with R&D and the CMO to drive early development decisions and portfolio strategy.

Ideal candidates bring MD/MD-PhD, 10+ years in clinical R&D, and proven ability to lead cross-functional teams, manage partnerships, and travel to global sites.