General Manager Data Management Solutions - Operations

Signant Health; United States; On-site; USD 200,000 - 260,000; Full time

Job summary

Signant Health is looking for a General Manager, Data Management Solutions in the United States to lead the Global Data Management function (RTSM, eCOA, sensors, EDC) with full P&L ownership and a multi‑year roadmap. You will shape strategy, drive growth, and direct a cross‑functional team across global sites.

The role requires deep CDMS/EDC and CDISC expertise, strong financial acumen, and executive communication.

Qualifications

• 15+ years in clinical data management within CRO/Pharma.
• 10+ years of senior leadership experience.
• Deep understanding of CRO/Pharma dynamics and global regulatory environment (GCP, 21 CFR Part 11).
• Experience hosting regulatory inspections and audits (FDA, EMA).
• Strong financial acumen with P&L ownership for a product or business line (e.g., EDC).
• Excellent executive communication and presentation skills.

Responsibilities

• Own full P&L, budget, and resource allocation for Data Management.
• Lead enterprise strategy and multi-year roadmap for Global Data Management.
• Provide strategic leadership and development for a high-performing Data Management organization.
• Set data quality, compliance, and audit readiness standards; lead audits (FDA/EMA).
• Represent Data Management capabilities to clients, prospects, and industry forums; support business development.
• Collaborate with Technical Delivery, Product/R&D, Commercial, and Project Management to align service levels.
• Govern KPI/SLA governance and risk management for the Data Management organization.

Skills

Strategic leadership

P&L ownership

Data management expertise

Regulatory knowledge

Executive communication

Cross-functional leadership

Client engagement

Education

Bachelor's degree in Statistics, CS, or Life Sciences

Advanced degree (MBA or MS) preferred

Tools

CDMS platforms

EDC platforms

CDISC SDTM/ADaM/CDASH

Job description

About Signant Health

At Signant Health, we help bring life-changing treatments to patients faster. We are a global evidence generation company that supports clinical trials with smart technology, scientific expertise, and hands‑on operational support — so better data leads to better decisions in healthcare. We embrace AI and advanced technologies to enhance every aspect of what we do, from data analysis to operational efficiency.

Our teams work at the intersection of science, technology, and patient experience, delivering digital solutions powered by AI innovation that make clinical trials more efficient, more accurate, and more accessible around the world. Trusted by leading pharmaceutical companies and CROs, our platforms and services support studies across more than 90 countries and have contributed to hundreds of new drug approvals.

If you are motivated by meaningful work, global impact, and innovation in clinical research and digital health — including the opportunity to work with cutting‑edge AI technologies — you will find purpose and opportunity at Signant Health.

We have an immediate opening for a General Manager, Data Management Solutions.

About the Role:

The General Manager, Data Management Solutions owns the strategic direction, organizational leadership, and overall performance of Signant Health's Global Data Management function, encompassing RTSM, eCOA, sensors, and EDC operations. This leader holds full profit‑and‑loss (P&L), budget, and resource allocation accountability for the Data Management organization — including direct P&L ownership of the EDC business line — and sets the enterprise vision and multi‑year roadmap for data management, ensuring Signant Health stays ahead of evolving CRO/Pharma industry demands, client expectations, and regulatory requirements. The General Manager also serves as Signant Health's foremost subject matter expert on clinical data management, representing the organization's capabilities to clients, prospects, and at industry conferences and forums, and works cross‑functionally with Technical Delivery, Product/R&D, Commercial, and Project Management leadership to ensure data management strategy and service delivery support business growth and client commitments.

Key Responsibilities:

• P&L & Business Ownership: Own full profit‑and‑loss, budget, and resource allocation accountability for the Data Management function — including direct P&L ownership of the EDC business line — ensuring investments support strategic initiatives, scalability, and profitable growth across RTSM, eCOA, sensors, and EDC.
• Strategy & Roadmap Leadership: Own the enterprise strategy and multi‑year roadmap for Global Data Management, keeping pace with emerging technology and the evolving CRO/Pharma regulatory landscape.
• Global Team Leadership: Provide strategic leadership, coaching, and development to build a high‑performing, cross‑functional Data Management organization, including hiring, retention, and succession planning for senior leaders.
• Quality, Compliance & Audit Readiness: Set enterprise standards for data quality, GCP/regulatory compliance, and CDISC standards (e.g., SDTM, ADaM, CDASH) across CDMS/EDC platforms; lead the organization's audit and regulatory inspection readiness, serving as executive point of contact during FDA, EMA, and client audits.
• Subject Matter Expertise & Client Engagement: Serve as Signant Health's foremost subject matter expert on clinical data management, representing the organization's capabilities to clients, prospects, and industry forums, and partnering with Commercial on strategic pursuits and client presentations.
• Cross‑Functional Collaboration: Partner closely with Technical Delivery, Product/R&D, Commercial, and Project Management leadership to ensure data management capabilities and service levels support client commitments and business growth.
• Performance & Risk Governance: Own governance of Key Performance Indicators (KPIs) and Service Level Agreements (SLAs) across the Data Management organization, presenting performance results and strategy updates to executive leadership; set risk management and business continuity strategy supporting global clinical trial delivery.

What You'll Bring:

• Bachelor's degree in a relevant field (Statistics, Computer Science, Life Sciences) or equivalent work experience; advanced degree preferred.
• 15+ years of progressive experience in clinical data management within the CRO/Pharma or clinical trials industry, including 10+ years of senior people management experience leading multi-team or multi‑site organizations.
• Deep understanding of CRO/Pharma industry dynamics, client expectations, and the global regulatory environment (GCP, 21 CFR Part 11) governing clinical data management, including RTSM, eCOA, and Clinical Data, with proven experience successfully hosting regulatory inspections and audits (e.g., FDA, EMA).
• Expert‑level knowledge of Clinical Data Management Systems (CDMS) and Electronic Data Capture (EDC) platforms and comprehensive understanding of CDISC standards (SDTM, ADaM, CDASH).
• Strong financial acumen, with proven experience owning full P&L (including for a product or business line such as EDC) or multi‑million dollar budgets and resource planning for a global organization.
• Strong executive communication and presentation skills, with proven ability to represent Data Management capabilities to clients, prospects, industry forums, and senior leadership, and to support business development and sales pursuits.

Nice to Have:

• Advanced degree (MBA, MS) in a relevant field.
• Experience working directly with CRO or Pharma clients in a service delivery or account leadership capacity.
• Familiarity with computer system validation principles, quality systems, and industry trends in clinical data technology.
• Experience representing an organization's data management capabilities to investors, partners, or at industry conferences and forums.