General Manager Data Management Solutions - Operations

Signant Health; Northern (KY); Hybrid; USD 180,000 - 240,000; Full time

Job summary

Signant Health seeks a General Manager, Data Management Solutions to lead strategy, P&L, and global delivery of RTSM, eCOA, sensors, and EDC platforms.

You will shape the multi‑year roadmap, build a high‑performing Data Management team, ensure data quality and regulatory readiness, and partner with Commercial, Product/R&D, and Delivery to drive growth and client success.

Qualifications

• Bachelors in Statistics, CS or Life Sciences or equivalent.
• 15+ years in clinical data management within CRO/Pharma or trials.
• 10+ years in senior people management across multi-team/sites.
• Expert knowledge of CDMS/EDC and CDISC standards (SDTM, ADaM, CDASH).
• Strong financial acumen with full P&L ownership or multi-million budgets.
• Excellent executive communication to clients, leadership, and forums.

Responsibilities

• Own full P&L, budget, and resource allocation for Data Management.
• Lead enterprise strategy and multi-year roadmap for Global Data Management.
• Provide strategic leadership and development for a high-performing team.
• Set data quality, regulatory compliance, and audit readiness standards.
• Represent Data Management to clients, prospects, and industry events.
• Collaborate with Technical Delivery, Product/R&D, Commercial, and PM leadership.
• Govern KPIs and SLAs; manage risk and business continuity.

Skills

Leadership

Strategic planning

Data management

Regulatory compliance

Budget management

Client engagement

Executive communication

Education

Bachelor's degree in Statistics, Computer Science, Life Sciences

Tools

CDMS

EDC

CDISC standards

Job description

About Signant Health

At Signant Health, we help bring life-changing treatments to patients faster. We are a global evidence generation company that supports clinical trials with smart technology, scientific expertise, and hands‑on operational support — so better data leads to better decisions in healthcare. We embrace AI and advanced technologies to enhance every aspect of what we do, from data analysis to operational efficiency.

Our teams work at the intersection of science, technology, and patient experience, delivering digital solutions powered by AI innovation that make clinical trials more efficient, more accurate, and more accessible around the world. Trusted by leading pharmaceutical companies and CROs, our platforms and services support studies across more than 90 countries and have contributed to hundreds of new drug approvals.

If you are motivated by meaningful work, global impact, and innovation in clinical research and digital health — including the opportunity to work with cutting‑edge AI technologies — you will find purpose and opportunity at Signant Health.

We have an immediate opening for a General Manager, Data Management Solutions.

About the Role:

The General Manager, Data Management Solutions owns the strategic direction, organizational leadership, and overall performance of Signant Health's Global Data Management function, encompassing RTSM, eCOA, sensors, and EDC operations. This leader holds full profit‑and‑loss (P&L), budget, and resource allocation accountability for the Data Management organization — including direct P&L ownership of the EDC business line — and sets the enterprise vision and multi‑year roadmap for data management, ensuring Signant Health stays ahead of evolving CRO/Pharma industry demands, client expectations, and regulatory requirements. The General Manager also serves as Signant Health's foremost subject matter expert on clinical data management, representing the organization's capabilities to clients, prospects, and at industry conferences and forums, and works cross‑functionally with Technical Delivery, Product/R&D, Commercial, and Project Management leadership to ensure data management strategy and service delivery support business growth and client commitments.

Key Responsibilities:

• P&L & Business Ownership: Own full profit‑and‑loss, budget, and resource allocation accountability for the Data Management function — including direct P&L ownership of the EDC business line — ensuring investments support strategic initiatives, scalability, and profitable growth across RTSM, eCOA, sensors, and EDC.
• Strategy & Roadmap Leadership: Own the enterprise strategy and multi‑year roadmap for Global Data Management, keeping pace with emerging technology and the evolving CRO/Pharma regulatory landscape.
• Global Team Leadership: Provide strategic leadership, coaching, and development to build a high‑performing, cross‑functional Data Management organization, including hiring, retention, and succession planning for senior leaders.
• Quality, Compliance & Audit Readiness: Set enterprise standards for data quality, GCP/regulatory compliance, and CDISC standards (e.g., SDTM, ADaM, CDASH) across CDMS/EDC platforms; lead the organization's audit and regulatory inspection readiness, serving as executive point of contact during FDA, EMA, and client audits.
• Subject Matter Expertise & Client Engagement: Serve as Signant Health's foremost subject matter expert on clinical data management, representing the organization's capabilities to clients, prospects, and industry forums, and partnering with Commercial on strategic pursuits and client presentations.
• Cross‑Functional Collaboration: Partner closely with Technical Delivery, Product/R&D, Commercial, and Project Management leadership to ensure data management capabilities and service levels support client commitments and business growth.
• Performance & Risk Governance: Own governance of Key Performance Indicators (KPIs) and Service Level Agreements (SLAs) across the Data Management organization, presenting performance results and strategy updates to executive leadership; set risk management and business continuity strategy supporting global clinical trial delivery.

What You'll Bring:

• Bachelor's degree in a relevant field (Statistics, Computer Science, Life Sciences) or equivalent work experience; advanced degree preferred.
• 15+ years of progressive experience in clinical data management within the CRO/Pharma or clinical trials industry, including 10+ years of senior people management experience leading multi-team or multi‑site organizations.
• Deep understanding of CRO/Pharma industry dynamics, client expectations, and the global regulatory environment (GCP, 21 CFR Part 11) governing clinical data management, including RTSM, eCOA, and Clinical Data, with proven experience successfully hosting regulatory inspections and audits (e.g., FDA, EMA).
• Expert‑level knowledge of Clinical Data Management Systems (CDMS) and Electronic Data Capture (EDC) platforms and comprehensive understanding of CDISC standards (SDTM, ADaM, CDASH).
• Strong financial acumen, with proven experience owning full P&L (including for a product or business line such as EDC) or multi‑million dollar budgets and resource planning for a global organization.
• Strong executive communication and presentation skills, with proven ability to represent Data Management capabilities to clients, prospects, industry forums, and senior leadership, and to support business development and sales pursuits.

Nice to Have:

• Advanced degree (MBA, MS) in a relevant field.
• Experience working directly with CRO or Pharma clients in a service delivery or account leadership capacity.
• Familiarity with computer system validation principles, quality systems, and industry trends in clinical data technology.
• Experience representing an organization's data management capabilities to investors, partners, or at industry conferences and forums.