Fall 2025 Post Doctoral Fellow - Peptide Synthesis

Sanofi; Cambridge (MA); On-site; USD 95,000; Full time

Job summary

Sanofi is seeking a Fall 2025 Post Doctoral Fellow focused on peptide synthesis. This role will involve developing workflows for drug substance manufacturing and executing innovative experiments. You'll work with advanced methodologies in a collaborative environment to push the boundaries of peptide chemistry, contributing to the future of drug development.

Benefits

Opportunities for professional growth

Exposure to cutting-edge technologies

Qualifications

• Must hold a Ph.D. by start date.
• Ability to relocate and work 40hrs/week.
• Strong background in synthetic chemistry.

Responsibilities

• Build a workflow for peptide synthesis.
• Develop new reactions focusing on noncanonical amino acids.
• Execute experimental plans for robust drug manufacturing processes.

Skills

Synthetic reaction transformations

Mechanistic analysis

Retrosynthetic analysis

Peptide synthesis techniques

Data analysis software

Education

Ph.D. in chemistry, chemical biology, or related field

Tools

Scifinder-n

Reaxys

Spotfire

Job description

Fall 2025 Post Doctoral Fellow - Peptide Synthesis

Join to apply for the Fall 2025 Post Doctoral Fellow - Peptide Synthesis role at Sanofi

Fall 2025 Post Doctoral Fellow - Peptide Synthesis

Join to apply for the Fall 2025 Post Doctoral Fellow - Peptide Synthesis role at Sanofi

Job Title: Fall 2025 Post Doctoral Fellow - Peptide Synthesis

Location: Cambridge, MA

About The Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

Join our dynamic team at Sanofi as a Postdoctoral Research Fellow focused on advancing the field of peptide synthesis as it relates to pharmaceutical and process development. In this role, you will contribute to a research area that centers on revolutionizing drug development by incorporating techniques of both solution-phase and solid-phase peptide synthesis (SPPS).

Specifically, this post-doctoral role is focused on: (1) developing a platform that establishes a workflow for route invention for peptide-derived drug substances and (2) applying lessons learned to scalable and process-friendly reaction development as it relates to the incorporation of noncanonical amino acids into larger peptides.

We are seeking an ambitious and innovative researcher who is passionate about pushing the boundaries of peptide synthesis. If you are excited about contributing to the development of state-of-the-art reaction design and process development within this discipline, we encourage you to apply and be part of our collaborative and forward-thinking research team at Sanofi.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

• Build a workflow for peptide synthesis within Sanofi CMC. This requires the implementation of new equipment and technologies and corresponding analytical techniques. Understanding of how the platform will be optimized for ease of use, speed and execution.
• New reaction development involving peptides emphasizing the incorporation of noncanonical amino acids.
• Design, plan and execute experimental plans, optimize reactions, purification and isolation unit operations, guided by technical risk assessments, to deliver safe, efficient, robust and scalable drug substance manufacturing processes that perform reliably at intended scale in batch or continuous format.
• Provide concise technical presentations to communicate work to project teams, cross functional teams and management. Document all work on projects and continuous improvements in eLNB experiments and summarize in technical reports
• Communicate scientific results/findings in an academic journal, patent or presentation.
  
  

About You

Basic Qualifications:

• Must hold or receive a Ph.D. in chemistry, chemical biology, or a related field from an accredited university by the time of the start date
• Must be able to relocate to the office location and work 40hrs/week, Monday-Friday, for the full duration of the PostDoc role.
  
  

Preferred Qualifications

• Proficient understanding of synthetic reaction transformations and in-depth expertise in mechanistic and retrosynthetic analysis.
• Expertise in various methods surrounding peptide synthesis: SPPS, liquid-tagged synthesis, solution-phase synthesis.
• Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire).
• Excellent written and oral communication skills
• Must have permanent US work authorization
  
  

Why Choose Us

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Exposure to cutting-edge technologies and research methodologies.
• Networking opportunities within Sanofi and the broader biotech community.
  
  

The salary for this position is $95,000 annually . All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through LINK.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Seniority level

• Seniority level

  Internship

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Pharmaceutical Manufacturing

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