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AstraZeneca plc in Tarzana, CA, seeks an experienced Facilities Maintenance Supervisor to lead maintenance operations supporting cell therapy manufacturing in a cGMP environment. You will drive reliability, ensure safety and compliance, and manage a team of technicians on a fast‑paced production floor.
Responsibilities include leading maintenance planning, enforcing SAP CMMS, conducting RCA/FMEA, and promoting a shift‑to‑predictive maintenance culture to sustain uninterrupted operations and
The Facilities Maintenance Supervisor leads maintenance operations to ensure the safe, compliant, and highly reliable performance of critical manufacturing and facility systems supporting cell therapy production in Tarzana, CA. In a Cell Therapy environment, where products are often patient‑specific and time‑sensitive, this role is critical to maintaining uninterrupted operations, cleanroom conditions, and strict chain‑of‑identity and chain‑of‑custody controls Tarzana, CA. The role integrates reliability engineering principles with daily maintenance execution, focusing on eliminating repeat failures, reducing unplanned downtime, and improving asset lifecycle performance in a highly regulated environment governed by FDA expectations and advanced therapies guidelines.
Success in this role requires the ability to:
Leadership & Team Management: Manage and mentor maintenance technicians; set clear expectations for safety, quality, and performance; lead daily tier meetings and shift handovers; build a culture of ownership, urgency, and continuous improvement; collaborate with Engineering, Quality, and Operations.
Maintenance Execution & Compliance: Ensure all activities meet GMP, FDA, and site standards; review and approve complete, accurate work orders; enforce CMMS usage (e.g., SAP); lead aspects of preventive and corrective maintenance and calibrations; maintain inspection readiness and support audits.
Reliability & Asset Management: Implement reliability‑centered maintenance; investigate failures using RCA and FMEA; improve MTBF and MTTR; identify and resolve “bad actor” equipment; partner on upgrades and lifecycle management.
Planning & Scheduling: Work with the Maintenance Planner to prioritize and schedule work; secure parts, tools, and permits in advance; validate and refine job plans; increase labor efficiency and minimize reactive work.
Safety, Health, and Environment (SHE): Enforce LOTO, confined space, and permit systems; conduct safety observations, audits, and incident investigations; lead by example to sustain a zero‑incident culture.
Continuous Improvement: Remove waste from maintenance processes; increase schedule compliance, PM efficiency, and spare‑parts management performance; lead or participate in Kaizen and Lean initiatives.
Work Environment: AZ is a cGMP regulated pharmaceutical manufacturing facility. We require your presence on the production floor and occasional off‑shift support This may involve gowning for cleanroom environments
High school diploma/GED required.8+ years in industrial facilities maintenance/leadership experience
4+ years of leadership experience in a pharmaceutical, biotech, or GMP regulated environment (medical device/food service may be acceptable.)
Technical diploma/apprenticeship in HVAC or Boiler maintenance.
Bachelor’s degree in Mechanical engineering or Facilities Management is a plus.
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The annual base salary for this position ranges from $89,874 to $134,812. However, base pay offered may vary depending on multiple individualized factors, including market location, job‑related knowledge, skills, and experience. In addition, our positions offer a short‑term incentive bonus opportunity; eligibility to participate in our equity‑based long‑term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).
Benefits offered include:
A qualified retirement program [401(k) plan]
Paid vacation, holidays, and paid leaves
Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.
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Date Posted
16-Oct-2026Closing Date
30-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.