Facilities Maintenance Supervisor

AstraZeneca GmbH; Los Angeles (CA); On-site; USD 90,000 - 135,000; Full time

Benefits offered by this job

401(k) plan

Paid vacation and holidays

Health benefits

Job summary

AstraZeneca seeks a Facilities Maintenance Supervisor to lead maintenance operations ensuring safe, compliant, and reliable performance of critical systems for cell therapy production in Tarzana, CA. You will balance speed, quality, and precision while enabling uninterrupted operations and cleanroom integrity.

Responsibilities include leading teams, enforcing GMP standards, improving reliability metrics, planning maintenance, and collaborating with Manufacturing, Quality, and Engineering to

Qualifications

• 8+ years in industrial facilities maintenance/leadership.
• 4+ years in pharmaceutical, biotech, or GMP environments.
• Experience on cleanroom floors and regulated facilities.

Responsibilities

• Lead maintenance teams; set safety, quality, and performance expectations.
• Ensure GMP/FDA-compliant maintenance, review work orders, and audits.
• Implement reliability-centered maintenance; drive MTBF/MTTR improvements.
• Coordinate planning and scheduling with parts, tools, and permits.
• Enforce safety systems (LOTO, confined space) and incident investigations.
• Champion Kaizen/Lean initiatives to reduce waste and boost efficiency.
• Work on-site in a cGMP pharmaceutical manufacturing facility.

Skills

Leadership

GMP compliance

Maintenance planning

Team coaching

Education

High school diploma or GED

Bachelor's degree in Mechanical engineering or Facilities Management

Tools

SAP CMMS

Calibration software

Job description

Position Summary:

The Facilities Maintenance Supervisor leads maintenance operations to ensure the safe, compliant, and highly reliable performance of critical manufacturing and facility systems supporting cell therapy production in Tarzana, CA. In a Cell Therapy environment, where products are often patient-specific and time-sensitive, this role is critical to maintaining uninterrupted operations, cleanroom conditions, and strict chain-of-identity and chain-of-custody controls Tarzana, CA. The role integrates reliability engineering principles with daily maintenance execution, focusing on eliminating repeat failures, reducing unplanned downtime, and improving asset lifecycle performance in a highly regulated environment governed by FDA expectations and advanced therapies guidelines.

Success in this role requires the ability to: Lead teams in a fast paced, patient-centric manufacturing environment Balance speed, compliance, and precision Anticipate and mitigate risks to critical, often irreplaceable batches Drive transition from reactive to predictive maintenance strategies Collaborate multi-functionally with Manufacturing, Quality, and Engineering to support 7 days cell therapy operations.

Ultimately, the Maintenance Supervisor plays a direct role in ensuring that life-saving therapies reach patients safely, reliably, and on time, by maintaining the integrity and performance of the systems that produce them.

Responsibilities:

• Leadership & Team Management: Manage and mentor maintenance technicians; set clear expectations for safety, quality, and performance; lead daily tier meetings and shift handovers; build a culture of ownership, urgency, and continuous improvement; collaborate with Engineering, Quality, and Operations.

• Maintenance Execution & Compliance: Ensure all activities meet GMP, FDA, and site standards; review and approve complete, accurate work orders; enforce CMMS usage (e.g., SAP); lead aspects of preventive and corrective maintenance and calibrations; maintain inspection readiness and support audits.

• Reliability & Asset Management: Implement reliability-centered maintenance; investigate failures using RCA and FMEA; improve MTBF and MTTR; identify and resolve "bad actor" equipment; partner on upgrades and lifecycle management.

• Planning & Scheduling: Work with the Maintenance Planner to prioritize and schedule work; secure parts, tools, and permits in advance; validate and refine job plans; increase labor efficiency and minimize reactive work.

• Safety, Health, and Environment (SHE): Enforce LOTO, confined space, and permit systems; conduct safety observations, audits, and incident investigations; lead by example to sustain a zero-incident culture.

• Continuous Improvement: Remove waste from maintenance processes; increase schedule compliance, PM efficiency, and spare-parts management performance; lead or participate in Kaizen and Lean initiatives.

• Work Environment: AZ is a cGMP regulated pharmaceutical manufacturing facility. We require your presence on the production floor and occasional off-shift support This may involve gowning for cleanroom environments

Minimum requirements:

• High school diploma/GED required.8+ years in industrial facilities maintenance/leadership experience
• 4+ years of leadership experience in a pharmaceutical, biotech, or GMP regulated environment (medical device/food service may be acceptable.)

Desirable:

• Technical diploma/apprenticeship in HVAC or Boiler maintenance.
• Bachelor’s degree in Mechanical engineering or Facilities Management is a plus.

The annual base salary for this position ranges from $89,874 to $134,812. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).

Our Benefits:

Benefits offered include:

• A qualified retirement program [401(k) plan]

• Paid vacation, holidays, and paid leaves

• Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.

#celltherapy

Date Posted: 12-Aug-2026

Closing Date: 25-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.