EXECUTIVE DIRECTOR, TRANSLATIONAL SCIENCE & CLINICAL BIOMARKERS

BioSpace; Redwood City (CA); On-site; USD 260,000 - 359,000; Full time

Benefits offered by this job

Competitive compensation package

Annual bonus & equity

401(k) with Roth match

Comprehensive health plans

PTO & holidays

Onsite facilities & shuttle

Job summary

Adicet Bio is seeking an Executive Director of Translational Science and Clinical Biomarkers to lead integrated translational and biomarker strategies across the portfolio as it advances γδ T cell therapies from IND through clinical development.

The role oversees biomarker programs, collaborates with cross-functional teams, and guides regulatory submissions while building a high-performing translational medicine team in a collaborative, onsite environment.

Qualifications

• PhD in immunology, cancer biology, molecular biology, or related field with 10–15+ years in biotech/pharma.
• Deep expertise in immunology and immuno-oncology.
• Proven leadership in translational medicine and biomarker strategy.
• Experience with cellular immunology and cell-based therapies (CAR-T/NK preferred).
• Experience supporting regulatory submissions (INDs, IBs) and biomarker components.

Responsibilities

• Lead translational science strategy across portfolio, informing target validation and efficacy.
• Oversee translational biomarker programs: assay development, validation, implementation.
• Collaborate with Clinical Development, Regulatory, CMC, Bioinformatics, and Nonclinical Research.
• Drive biomarker and precision medicine strategies including companion diagnostics.
• Provide portfolio-level oversight of timelines, budgets, and milestones.
• Represent translational sciences in governance and regulatory submissions.
• Establish external collaborations with CROs and academia.
• Build and mentor a high-performing translational medicine team.

Skills

Leadership

Translational medicine

Biomarkers

Immunology

Cross-functional teamwork

Regulatory submissions

Education

PhD in immunology/cancer biology/molecular biology or related

Job description

Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.

EXECUTIVE DIRECTOR, TRANSLATIONAL SCIENCE & CLINICAL BIOMARKERS

Adicet Bio is seeking an Executive Director of Translational Science and Clinical Biomarkers to provide strategic leadership in advancing γδ T cell–based therapies from IND through clinical development. This individual will define and lead integrated translational and clinical biomarker strategies across the portfolio, enabling the successful translation of novel cell therapy programs from preclinical research into clinical studies.

The Executive Director will guide the design and implementation of clinical biomarker approaches to inform mechanism of action, pharmacokinetics, pharmacodynamics, patient selection, and clinical decision‑making, supporting product candidates through first‑in‑human and subsequent clinical trials in close collaboration with cross‑functional teams.

Key Responsibilities

• Leads the translational science strategy across Adicet Bio’s portfolio, integrating clinical biomarker strategies to inform target validation, clinical efficacy, and potential diagnostic development strategy.
• Provides executive oversight of translational biomarker programs, ensuring robust assay development, validation, and implementation to support clinical trials and decision‑making.
• Partners cross‑functionally with Clinical Development, Regulatory, CMC, Bioinformatics, and Nonclincal Research to advance translational strategies from discovery through clinical development.
• Drives biomarker and precision medicine strategies, including the development and regulatory advancement of companion diagnostics and patient‑selection approaches.
• Provides portfolio‑level oversight of translational programs, ensuring alignment of timelines, budgets, and deliverables with corporate milestones and clinical development goals.
• Represents translational sciences in governance and program leadership teams, influencing key development decisions and advancing platform capabilities.
• Leads preparation and review of translational/clinical biomarker components for regulatory submissions (e.g., INDs, IBs, BLAs), clinical protocols, and external scientific communications including abstracts and manuscripts.
• Establishes and manages strategic external collaborations with CROs, academic partners, and diagnostic companies to advance biomarker and translational initiatives.
• Builds and develops a high‑performing translational medicine team, providing mentorship, scientific leadership, and organizational development.

Qualifications

• PhD in immunology, cancer biology, molecular biology, or a related discipline with 10–15+ years of relevant experience, including significant experience in the biotechnology or pharmaceutical industry.
• Deep expertise in immunology and immuno‑oncology, with a strong understanding of the tumor microenvironment, immune regulation, and mechanisms of immune dysfunction across oncology, autoimmunity, and other immune‑mediated diseases.
• Demonstrated leadership in translational medicine and biomarker strategy, with experience advancing programs from IND to early and late stages of clinical development across oncology and/or immune‑mediated disease indications.
• Experience with cellular immunology and cell‑based therapeutics, including in‑depth characterization of T cells, NK cells, and/or CAR‑T/NK products, strongly preferred.
• Proven track record of leading cross‑functional teams and influencing development strategy across research, translational medicine, and clinical development.
• Experience supporting regulatory submissions (e.g., INDs, IBs) and contributing to biomarker and translational components of clinical development programs.
• Strong leadership, communication, and collaboration skills, with the ability to effectively engage internal stakeholders, external partners, and senior leadership.
• Experience building and mentoring high‑performing scientific teams, fostering innovation and advancing translational capabilities across the organization.

Adicet fosters a collaborative, high‑performing environment by prioritizing in‑person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full‑time onsite presence.

Pay Range

$260,000 - $359,000 USD

Benefits and Perks

• We offer a competitive compensation package including base salary, annual cash bonus, long‑term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.
• To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long‑term disability insurance, and legal, pet, and various other voluntary insurance programs.
• We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time‑off including 13 company holidays, paid end‑of‑year winter break, vacation, sick time, and paid parental leave.
• Adicet is located in a state‑of‑the‑art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company‑subsidized lunches (delivered onsite daily) and fully stocked breakrooms.

Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.