Executive Director, Clinical Supply Chain

Revolution Medicines; San Francisco (CA); On-site; USD 265,000 - 331,000; Full time

Job summary

A leading oncology firm in San Francisco is seeking a professional to lead the clinical supply chain strategy. The role involves developing supply chain processes to support clinical programs, managing vendor relations, and ensuring compliance with regulatory standards. Candidates must have over 20 years of experience in pharmaceutical supply chains, strong leadership and communication skills. The position offers a salary range of $265,000 - $331,000 for a full-time onsite role.

Qualifications

• 20+ years in pharmaceutical supply chain, or 18+ years with a Master's degree.
• 5+ years in a leadership/supervisory role.
• Strong knowledge of end-to-end supply chain and demand/supply planning.

Responsibilities

• Define and execute global clinical supply chain strategy.
• Oversee end-to-end clinical supply activities.
• Ensure compliance with GxP, ICH, FDA, EMA requirements.

Skills

Supply Chain Management

Leadership

Vendor Management

Communication Skills

cGMP Operations

Education

Bachelor’s degree in Supply Chain, Business, Engineering or Life Sciences

Master’s degree (MS, MBA)

CPIM/CSCP certifications

Job description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

• Define and execute the global clinical supply chain strategy aligned with the company’s clinical development pipeline and long‑term business goals.
• Establish processes to ensure uninterrupted supply for Revolution Medicines portfolio across all phases of development.
• Lead and serve as subject‑matter expert for clinical supply chain planning, risk management, and execution of clinical supply chain activities.
• Build scalable processes and infrastructure to support early‑through late‑phase clinical programs.
• Strategic planning for comparator sourcing management to ensure timely, compliant and cost‑effective product availability.
• Effective management of clinical studies executed with collaboration partners.
• Identify and implement overall clinical supply chain best practices.

Clinical Supply Operations

• Oversee end‑to‑end clinical supply activities, including demand forecasting, protocol reviews, packaging, labeling, distribution, and returns.
• Ensure uninterrupted supply of investigational medicinal products (IMP), including RevMed and comparator products.
• Champion monthly Development Operations Planning (DnOP) process in collaboration with PDM and Clinical Operation team members.
• Ensure efficient global clinical supply chain distribution networks are in place.
• Oversee comparator products demand and supply planning with expert knowledge in comparator drugs and co‑medications sourcing strategy.

Cross‑Functional Collaboration

• Partner with Clinical Operations and Clinical Study Execution Teams (CSET) in study planning and execution.
• Collaborate with PDM, Quality, and Regulatory to ensure compliant manufacturing, labeling, and distribution.
• Work closely with Finance on budgeting, forecasting, and cost optimization.
• Work effectively with internal and external partners to develop sound strategies, identify and mitigate risks, and resolve issues as they arise.

Compliance & Quality

• Ensure all clinical supply activities comply with GxP, ICH, FDA, EMA, and global regulatory requirements.
• Expert knowledge of applicable GxP requirements and applicable regulatory guidances.
• Lead inspection readiness activities as required for global filings and maintain inspection‑ready organization.

Team Leadership

• Build, lead, and mentor a high‑performing clinical supply chain organization. Drive excellence in execution of agreed‑upon strategies.
• Establish clear performance metrics, development plans, and succession planning.
• Foster a culture of accountability, continuous improvement, and collaboration.
• Drive excellence in setting clear and actionable team goals.

Required Skills, Experience and Education

• Bachelor’s degree in Supply Chain, Business, Engineering or Life Sciences with 20+ years of experience in pharmaceutical supply chain. Master’s degree (MS, MBA) with at least 18 years of experience in pharmaceutical/biotech supply chain.
• CPIM/CSCP certifications are a plus.
• At least 5 years of experience in a leadership/supervisory role.
• Strong knowledge and experience with cGMP operations for small molecules, end‑to‑end supply chain and demand/supply planning.
• Effective vendor management and oversight skills.
• Excellent cross‑functional leadership skills with effective communication.

Preferred Skills

• Proven leadership experience hiring, managing and developing teams.
• Knowledge and experience with outsourced manufacturing operations (CMO’s).
• Effective, open and transparent communication skills (verbal and written). Strong analytical, communication and executive‑level reporting skills.
• Capable of working on multiple projects/tasks and able to meet timelines.
• Self‑starter with a high‑level of comfort with ambiguity and complexity and the ability to multi‑task while consistently delivering quality results.
• Team‑oriented, progressive thinker who enjoys participating in an innovative and creative work environment.

Base Pay Salary Range: $265,000 - $331,000 USD for a full‑time position onsite at our headquarters in Redwood City, CA.

Revolution Medicines is an equal‑opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.