Executive Director, Clinical PK & Pharmacometrics

Clutch Canada; United States; On-site; USD 230,000 - 320,000; Full time

Job summary

Liquidia seeks an Executive Director of Clinical Pharmacokinetics to lead PK and pharmacometrics across the portfolio, translating clinical pharmacology into actionable development strategies at asset, study, and population levels.

The role requires expertise in inhaled drug development, exposure‑response modeling, and regulatory interactions, reporting to the Chief Development Officer. Collaborate with Clinical Development, Regulatory, Biostatistics, CMC, and external teams.

Qualifications

• Strong understanding of drug development, clinical pharmacology, PK and modeling.
• Experience with inhaled drug development and PK considerations.
• Experience with exposure‑response and pharmacodynamic modeling.
• Experience with population PK/pharmacometrics platforms (e.g., NONMEM, Monolix).

Responsibilities

• Provide PK leadership across drug development programs from preclinical to regulatory submission.
• Develop and implement integrated PK/clinical pharmacology strategies.
• Oversee PK sampling, data management, and bioanalytical requirements.
• Interpret PK results and translate into development recommendations.
• Collaborate with cross‑functional teams and regulators on PK strategies.

Skills

Inhaled drug development

Exposure‑response modeling

Pharmacometric modeling

Population PK

NONMEM/Monolix

Pharmacodynamics modeling

MIDD

PBPK modeling

Dose selection

Special populations

DDI assessment

Regulatory interactions

Scientific leadership

Tools

NONMEM

Monolix

Job description

Liquidia seeks an Executive Director of Clinical Pharmacokinetics to lead PK and pharmacometrics across the portfolio, translating clinical pharmacology into actionable development strategies at asset, study, and population levels.

The role requires expertise in inhaled drug development, exposure‑response modeling, and regulatory interactions, reporting to the Chief Development Officer. Collaborate with Clinical Development, Regulatory, Biostatistics, CMC, and external teams.