Executive Director, Chemical Engineering Lead

Madrigal Pharmaceuticals Inc.; Conshohocken (Montgomery County); On-site; USD 276,000 - 329,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

Flexible PTO

401(k)

Job summary

Madrigal is seeking a lead for scale-up engineering who will ensure DS/DP processes are scalable, safe, and transferable to external manufacturing. You will define equipment and process fit, drive safety reviews, and support validation readiness.

Requires BS in Chemical Engineering with 18+ years in GMP manufacturing and tech transfer, strong leadership, cross-functional influence, and a track record of improvements. The role offers equity, comprehensive benefits, and a competitive base salary.

Qualifications

• BS in Chemical Engineering or equivalent; advanced degree preferred.
• 18+ years in process/chemical engineering for GMP manufacturing/tech transfer.
• Demonstrated leadership in scale-up, safety, and external manufacturing collaboration.
• Strong cross-functional influence and structured problem solving.
• Experience with tech transfer readiness and risk assessments.

Responsibilities

• Set engineering standards for scale-up readiness, safety, and process/equipment fit
• Support DS/DP teams in defining scalable process parameters and operating ranges
• Lead engineering input to tech transfer, process safety reviews, and risk assessments
• Drive yield/throughput/cycle-time improvement opportunities with external partners
• Ensure engineering documentation supports validation readiness and audit expectations

Skills

Leadership

Cross-functional

Problem solving

Documentation

Continuous improvement

Tech transfer

Education

BS in Chemical Engineering

Advanced degree preferred

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Leads chemical engineering strategy and execution oversight to ensure DS/DP processes are scalable, safe, and transferable to external manufacturing. Defines equipment/process suitability expectations, drives process safety and manufacturability assessments, and supports resolution of scale-up constraints. Ensures engineering inputs align with validation strategy and sustained performance post-transfer, enabling reliable supply execution.

Key Responsibilities

• Set engineering standards for scale-up readiness, safety, and process/equipment fit
• Support DS/DP teams in defining scalable process parameters and operating ranges
• Lead engineering input to tech transfer, process safety reviews, and risk assessments
• Drive yield/throughput/cycle-time improvement opportunities with external partners
• Ensure engineering documentation supports validation readiness and audit expectations

Required Qualifications

• BS+ in Chemical Engineering (advanced degree preferred)
• 18+ years in process/chemical engineering supporting GMP manufacturing/tech transfer
• Demonstrated leadership in scale-up, safety, and external manufacturing collaboration
• Strong cross-functional influence and structured problem solving

Preferred Qualifications

• Experience supporting SDD process scale-up and solvent/safety considerations
• Experience supporting validation/PPQ readiness activities

Key Competencies

• Scale-up engineering, process safety, and manufacturability
• Tech transfer readiness and constraint resolution
• Continuous improvement and performance-focused execution
• Documentation rigor and stakeholder communication

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $276,205 - $328,644 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [e-mail].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.