Executive Director, Analytical Chemistry Lead

Madrigal; Conshohocken (Montgomery County); On-site; USD 276,000 - 329,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

401(k) with match

Flexible PTO

Job summary

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for MASH. We seek an analytical development leader to define strategy, oversee method development, and ensure robust data for DS/DP decisions and regulatory filings.

In this role, you will lead cross-functional collaborations, manage external partners, and drive lifecycle management with a focus on data integrity and compliance. Equity and strong benefits accompany a competitive salary.

Qualifications

• BS+ in Analytical Chemistry or related; advanced degree preferred.
• 18+ years analytical development experience in regulated environment.
• Leadership of method strategy, data integrity, and external partner oversight.
• Strong cross-functional communication and documentation skills.

Responsibilities

• Define analytical strategy and prioritization across assets (release, stability, in-process).
• Ensure method development/qualification plans meet program timelines and decisions.
• Govern external analytical execution, data review standards, and issue escalation.
• Align specs, reference standards, and analytical justifications with DS/DP strategy.
• Ensure analytical sections and rationales are ready for CMC authoring and filings.

Skills

Analytical method development

Leadership

Cross-functional collaboration

Documentation

Data integrity

Education

BS+ in Analytical Chemistry or related

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. Owns analytical development strategy and execution oversight to ensure fit-for-purpose methods and characterization packages support DS/DP decisions, release readiness, and stability programs. Establishes method lifecycle expectations, data integrity standards, and external lab governance to maintain reliable, traceable data. Partners with DS/DP and CMC Strategy to align specifications, reference standards, and analytical rationales within a phase-appropriate control strategy.

Key Responsibilities

• Define analytical strategy and prioritization across assets (release, stability, in-process).
• Ensure method development/qualification plans meet program timelines and decisions.
• Govern external analytical execution, data review standards, and issue escalation.
• Align specs, reference standards, and analytical justifications with DS/DP strategy.
• Ensure analytical sections and rationales are ready for CMC authoring and filings.

Required Qualifications

• BS+ in Analytical Chemistry or related (advanced degree preferred)
• 18+ years analytical development experience in regulated environment
• Demonstrated leadership of method strategy, data integrity, and external partner oversight
• Strong cross-functional communication and documentation skills

Preferred Qualifications

• Experience supporting solid-state characterization strategies and polymorph programs
• Experience supporting pharmaceutical regulatory filings and HA responses

Key Competencies

• Analytical method lifecycle management and scientific rigor
• Data integrity mindset and investigation/troubleshooting leadership
• Spec/control strategy alignment and documentation clarity
• Vendor governance and cross-functional influence

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $276,205 - $328,644 per year. We comply with all applicable minimum wage laws.

• All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create.
• Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans.
• We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings.
• In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family.
• The company also provides other benefits in accordance with applicable federal, state, and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [e-mail].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.