Executive Director, Biotherapeutics DMPK

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 268,000 - 402,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Total rewards benefits

Job summary

Vertex Pharmaceuticals Inc is seeking an Executive Director, Biotherapeutics DMPK-BA to lead strategy for protein, antibody, ADC, and cell/gene therapies. Based in Boston, you will oversee DMPK-BA across Boston and Seattle and align with Global DMPK leadership.

You will integrate PK, bioanalysis, ADME and translational PKPD to inform dose selection and program decisions, while building cross-functional partnerships.

Qualifications

• 15+ years of industry experience at management level in DMPK-BA
• Experience with multiple biotherapeutic modalities (protein, antibody, ADC, cell/gene therapies)
• Excellent communication and cross-site collaboration skills

Responsibilities

• Develop vision, strategy, and capabilities for Biotherapeutics DMPK-BA across Boston and Seattle
• Integrate PK, ADME, bioanalysis, and translational PKPD data to support dose selection and program decisions
• Provide clear communication of findings and recommendations to senior leadership and governance bodies
• Build and maintain strong collaborations with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R&D disciplines
• Hire, develop, and retain high-performing DMPK-BA talent and manage cross-site resources

Skills

DMPK-BA strategy

Cross-functional leadership

Strategic decision-making

Mentoring & people mgmt

Education

PhD in Pharmacokinetics/Biochemistry/Biology

Job description

Job Description General Summary:

We are seeking an accomplished and strategic leader to serve as Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA), to guide the DMPK-BA strategy for our rapidly growing Biotherapeutics portfolio that includes protein, antibody, ADC, and cell and genetic therapies. The responsibilities will span from early research through development. This leader will be based in Boston but manage and oversee the work of DMPK-BA teams at our Vertex Biologics and Cell and Genetic Therapies sites in Boston and Seattle and will be part of the Global DMPK leadership team. He/she will play a central role in integrating PK, bioanalysis, ADME, and translational PKPD data and insights into cross-functional program decision-making and development plans and help shape the direction of overall Vertex portfolio. The ideal candidate will bring deep strategic and scientific expertise in DMPK-BA for one or more biotherapeutic modalities described above, have demonstrated record of people management and leadership in a direct line as well as matrixed environment, and will have the ability to influence cross-functional teams and governance bodies at Vertex.

Key Responsibilities

Develop vision, strategy, and capabilities for the Biotherapeutics DMPK-BA teams across Boston and Seattle sites that is aligned with the Global DMPK-BA and Vertex R&D vision/mission. Develop and execute DMPK-BA scientific strategies from discovery through clinical development including design, execution, and interpretation of preclinical PK, ADME, bioanalytical and immunogenicity assays for biotherapeutics, and translational PKPD approaches to support dose selection and clinical projections. Provide clear communication of DMPK-BA findings, implications, and recommendations to team members, senior leadership, and Vertex R & D governance bodies to advance Vertex programs through discovery and development. Build and maintain strong collaborative partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R & D disciplines to align DMPK-BA strategy with overall program goals. Implement innovative technologies and approaches to enhance scientific impact and/or efficiencies. Provide scientific and managerial leadership to the team in prioritizing and executing on key deliverables and project needs. Ensure scientific excellence and regulatory compliance in all necessary DMPK regulatory documents and reports to support drug development including investigator brochures, INDs (or equivalent), and marketing applications. Hire, develop, manage, and retain key talent to maintain a high-performing team. Develop internal and external sourcing strategies and liaise across sites to best meet project needs. Contribute to developing Global DMPK-BA resource allocation, staffing needs, expenses, and capital budget and implementation plans. Participate in review of business development opportunities.

Qualifications

PhD in Pharmacokinetics, Biochemistry, Biology, or related field, with 15+ years of industry experience at the management level Successful track record and experience managing DMPK-BA teams across more than one therapeutic area. Extensive experience working with one or more biotherapeutic modalities (e.g., protein, antibody and nucleic acid therapeutics, cell and gene therapies) is a must. Deep scientific and strategic expertise in various components of DMPK science such as PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling approaches for biologics. Excellent communication skills and ability to develop and grow strong cross-site/function collaborations. Ability to critically evaluate and implement new science and technology as it relates to the discovery and development of new medicines. Experience preparing regulatory submissions and interacting with health authorities. Strong management and leadership skills, with emphasis on developing and mentoring emerging talent. #LI-KM4

Pay Range: $268,000 - $402,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.