Executive Director, Biotherapeutics DMPK

Scorpion Therapeutics; Boston (MA); Hybrid; USD 268,000 - 402,000; Full time

Job summary

Scorpion Therapeutics in Boston/Seattle seeks an Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA) to guide strategy across teams, integrating PK, bioanalysis, ADME and translational PKPD into program decisions. You will hire and mentor teams, manage budgets, and drive regulatory-compliant DMPK documents. Lead cross-functional partnerships and source opportunities.

Qualifications

• PhD required with 15+ years senior leadership experience in DMPK-BA.
• Proven track record leading DMPK-BA across multiple therapeutic areas including biologics.
• Strong communication and cross-site collaboration skills.

Responsibilities

• Develop vision and strategy for Biotherapeutics DMPK-BA aligned with Global DMPK-BA and Vertex R&D.
• Lead DMPK-BA programs from discovery through clinical development including PK/ADME/bioanalysis.
• Communicate findings and recommendations to senior leadership and governance bodies.

Skills

Leadership

DMPK-BA

Biotherapeutics

Cross-functional collaboration

Regulatory submissions

Mentoring

Education

PhD in Pharmacokinetics/Biochemistry/Biology or related field

Job description

General Summary

Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA) to guide DMPK-BA strategy across Boston and Seattle teams (Vertex Biologics and Cell & Genetic Therapies) as part of the Global DMPK leadership team. Integrate PK, bioanalysis, ADME, and translational PKPD insights into cross-functional program decisions and development plans.

Key Responsibilities

• Develop vision, strategy, and capabilities for Biotherapeutics DMPK-BA teams aligned with Global DMPK-BA and Vertex R&D.
• Develop and execute DMPK-BA scientific strategies from discovery through clinical development (preclinical PK, ADME, bioanalytical and immunogenicity assays; translational PKPD for dose selection/clinical projections).
• Communicate DMPK-BA findings, implications, and recommendations to teams, senior leadership, and governance bodies.
• Build cross-functional partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R&D disciplines.
• Implement innovative technologies/approaches to improve impact and/or efficiency.
• Provide scientific and managerial leadership for prioritization and delivery of key projects.
• Ensure scientific excellence and regulatory compliance for DMPK documents/reports (investigator brochures, INDs/equivalents, marketing applications).
• Hire, develop, manage, and retain talent.
• Drive internal/external sourcing; contribute to resource allocation, staffing, expenses, capital budget, and implementation plans.
• Participate in review of business development opportunities.

Qualifications

• PhD in Pharmacokinetics, Biochemistry, Biology, or related field; 15+ years industry experience at management level.
• Track record managing DMPK-BA teams across more than one therapeutic area; extensive experience with biotherapeutic modalities (protein, antibody/nucleic acid therapeutics, cell and gene therapies).
• Deep expertise in PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling for biologics.
• Excellent communication; ability to build cross-site/function collaborations.
• Ability to evaluate and implement new science/technology.
• Experience preparing regulatory submissions and interacting with health authorities.
• Strong management/leadership with mentoring of emerging talent.

Pay Range: $268,000 - $402,000 Annual bonus and annual equity awards.