Executive Assistant, Technical Operations

Madrigal Pharmaceuticals; Waltham (MA); On-site; USD 104,000 - 127,000; Full time

Benefits offered by this job

Base salary

Equity

Comprehensive benefits

Mental health benefits

Job summary

Madrigal Pharmaceuticals, based in Waltham, MA, is seeking an Executive Administrative Assistant to provide strategic administrative support to the Executive Vice President, Technical Operations and the leadership team. This role requires executive presence, discretion, and the ability to manage shifting priorities in a fast-paced biotech environment.

The position is based in the Waltham, MA office and requires onsite presence at least three days per week.

Qualifications

• 10+ years of progressive administrative experience, including direct support of C-level executives.
• Ability to manage complex schedules, shifting priorities, and high-visibility work.
• Strong judgment, executive presence, and stakeholder management skills.
• Highly organized, proactive, and solutions-oriented.
• Advanced proficiency in Microsoft Office Suite.

Responsibilities

• Strategically maintain complex calendars and schedules for executive leadership.
• Proactively anticipate conflicts, coordinate travel, and protect executive focus.
• Serve as primary liaison between executives and internal/external stakeholders.
• Coordinate and monitor end-to-end executive travel and itineraries.
• Develop detailed travel itineraries and contingency plans.
• Manage and reconcile executive expenses with accuracy and compliance.
• Coordinate leadership team meetings, agendas, and follow-up on actions.
• Provide high-level administrative and operational support to leadership.
• Develop and maintain efficient systems for information, documents, and workflows.
• Lead or support cross-functional projects and initiatives.
• Mentor and support the broader administrative staff.
• Handle sensitive information with the highest level of confidentiality.

Skills

Executive presence

Stakeholder management

Calendar management

Problem solving

Organizational agility

Discretion and confidentiality

Education

Bachelor’s degree preferred

Tools

Microsoft Office Suite

Outlook

PowerPoint

Word

Excel

Teams

SharePoint

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction‑associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration.

The Executive Administrative Assistant provides high‑level, strategic administrative and operational support to the Executive Vice President, Technical Operations and the Technical Operations leadership team. This role serves as a trusted partner to their executive leaders, ensuring seamless operational execution, proactive prioritization, and exceptional coordination across Quality, Supply Chain and CMC, and cross‑collaboration with all other departments.

This role is highly visible and requires executive presence, sound judgment, discretion, and the ability to anticipate needs in a fast‑paced, growth‑oriented biotech environment. The ideal candidate operates with a strategic mindset, demonstrates exceptional organizational agility, and thrives in managing complex, shifting priorities while maintaining absolute confidentiality.

The position is based in the Waltham, MA office and requires onsite presence at least three days per week.

Key Responsibilities

• Strategically maintain complex calendars and schedules for executive leadership.
• Proactively anticipate conflicts, recommend trade‑offs, and protect executive focus.
• Serve as a primary liaison between executives and internal/external stakeholders, representing executive leadership with professionalism, discretion, and sound judgment.
• Coordinate and proactively monitor end‑to‑end executive travel, providing real‑time support to resolve delays, disruptions, or logistical challenges while minimizing impact to executive schedules.
• Develop detailed travel itineraries and contingency plans aligned with executive priorities and business needs.
• Manage and reconcile executive expenses with accuracy, timeliness, and adherence to company policies and compliance requirements.
• Coordinate leadership team meetings, agendas, and follow‑up on key actions and deliverables.
• Provide high‑level administrative and operational support critical to leadership effectiveness.
• Develop and maintain efficient systems for information, documents, and workflows.
• Lead or support cross‑functional projects and operational initiatives.
• Partner with and support the broader administrative team to ensure continuity and coverage.
• Serve as a mentor and informal leader to the broader administrative staff.
• Handle sensitive information with the highest level of confidentiality and professionalism.

Travel Requirement

• Some travel is required for team off‑site meetings, visits to the Conshohocken, PA office, and potentially other meetings such as Executive Leadership Team off‑sites and Board of Directors meetings.

Required Qualifications

• 10+ years of progressive administrative experience, including direct support of C‑level executives.
• Proven ability to manage complex schedules, shifting priorities, and high‑visibility work.
• Strong judgment, executive presence, and stakeholder management skills.
• Highly organized, proactive, and solutions‑oriented.
• Advanced proficiency in Microsoft Office Suite (Outlook, PowerPoint, Word, Excel, Teams, SharePoint).

Desired Qualifications

• Bachelor’s degree preferred.
• Prior experience in a biotech, pharmaceutical, or publicly traded company strongly preferred.
• Experience supporting finance, business development, or other corporate leadership functions.

Benefits

• Base salary of $104,000–$127,000 per year (paid in accordance with applicable minimum wage laws).
• Equity in the company to reinforce ownership culture and align with company performance.
• Comprehensive benefits including flexible paid time off, medical, dental, vision, life and disability insurance, 401(k) with employer match, and supplemental life insurance, legal services and other voluntary benefits.
• Mental health benefits through our Employee Assistance Program for employees and their families.

Accommodation and Equal Opportunity

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [e-mail].

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran status, or other characteristics protected by applicable federal, state, or local law.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

We have received reports of individuals misrepresenting themselves as Madrigal hiring managers and soliciting upfront fees or personal information. Such individuals are fraudsters. Madrigal does not conduct interviews via text or chat rooms and does not offer positions without a thorough recruiting process. Any correspondence regarding employment will come from an authorized madrigalpharma.com email address or a trusted search firm partner. If you receive unsolicited offers, please do not respond or open attachments or click links. For any questions about the legitimacy of contacts, direct them to [e-mail].